Protein Alignment Ugt37D1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_001285989.1
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 150/544 - (27%)
• Similarity: 267/544 - (49%)
• Gaps: 92/544 - (16%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKS----INHIVVPMSAEDEKV--LNDGMAGM-V 102
            ||::....|::.|.::.|||||::|......:.:    :|..|:|:|.:...:  |.:.|..: :
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly   103 KEKP---SIWNTMKSIFSSLALLIDK--QVD------VLEDPRFQELYLNKGNKFDVVFVGFFFN 156
            ..:|   :||    :.:..|..|:|.  |::      ||::|:.. ..|.||. |||:...
Human   306 DHRPTPLTIW----AFYKELGKLLDTFFQINIQLCDGVLKNPKLM-ARLQKGG-FDVLVAD---- 360

  Fly   157 TYQVALGARFNCPVIISWSGPPMMMVNEVLGNPEL-------SSVPQMH---ISAPPG------- 204
                        ||.|...     :|...||.|.:       :|..:.|   |.||..
Human   361 ------------PVTICGD-----LVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALS 408

  Fly   205 ---QPMNFQQRMQNFASTLGFNALN-IFLNH--KYNKFYDRLWSKDKSMPTFAQAKRNVSLAFCN 263
               ..|.|.:|::|   |:.::..: ||.::  ::|.:|.::..:.   .|..:......:....
Human   409 ELTDQMTFGERIKN---TISYSLQDYIFQSYWGEWNSYYSKILGRP---TTLCETMGKAEIWLIR 467

  Fly   264 GHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEV 327
            .:...|.| ||.:|....:||:..| ...|||::::||:: .||:|.::|||||.:|  ::..|.
Human   468 TYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NLTEEK 528

  Fly   328 VKTIFKGLSSLKQQVIWKWEDPK-NTPGKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEA 391
            ...|...|:.:.|:|:|:::..| .|.|.:..:.  .|:||:|:|.|||.|.||||.|..|:.||
Human   529 ANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGIYEA 591

  Fly   392 QYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQL 456
            .||||||:.:|:|||||.|...:.|.|..:::.|.|:...:..:|::.||..|.|.:.....|::
Human   592 IYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRI 656

  Fly   457 YRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI--YIIAALVLYIVFIINKIV 519
            :.|:|:.|.:..|:|.|:|:||.||.|::.....:.:...::||:  :::..:...|..:|...:
Human   657 HHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCL 721

  Fly   520 WKFVWRKLFGKSNKVSKGKKVKKQ 543
              |..:| |||.     |||.|::
Human   722 --FSCQK-FGKI-----GKKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	139/511 (27%)
		UDPGT	45..530	CDD:278624	144/529 (27%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	142/524 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150217
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840