Protein Alignment Ugt37D1 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_652627.2
• Gene: Ugt37D1 / 53511
• FlyBaseID: FBgn0040260
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 144/534 - (26%)
• Similarity: 248/534 - (46%)
• Gaps: 75/534 - (14%)

  Fly    45 SHFIVHMSIMKTLAEKGHNVTVVSS------------------VPPKVTHKSINHIVVPMSAEDE 91
            ||::...:|:|.|.::||.|||::|                  .|..:|.....:|::.......
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    92 KVLNDGM-AGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFF 155
            .:..|.. ....:|:..:|. :..||.:....:.....|::  :.||      ::||:||....|
Human    99 DIRKDSFWLYFSQEQEILWE-LYDIFRNFCKDVVSNKKVMK--KLQE------SRFDIVFADAVF 154

  Fly   156 NTYQVALGARFNCPVIISWSGPPMMMVNEVLGN----PELSSVPQMHISAPPGQPMNFQQRMQNF 216
            ...:: |.|..|...:.|....|...:....|.    |....:....:|    ..|.|.:|::|.
Human   155 PCGEL-LAALLNIRFVYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLS----DQMTFMERVKNM 214

  Fly   217 ASTLGFNA-LNIFLNHKYNKFYDRLWSKDKSM-PTFAQA----KRNVSLAFCNGHGISEGPIRPN 275
            ...|.|:. ..:....|:::||..:..:..:: .|..:|    .|| |.:|...|        |.
Human   215 IYVLYFDFWFQMSDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRN-SWSFQFPH--------PF 270

  Fly   276 VPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLK 339
            :|.|..:||...| ...|||::::||:: .|::|.::|||||.:  .::..|....|...|:.:.
Human   271 LPNVDFVGGFHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIP 332

  Fly   340 QQVIWKWEDPKNTP-GKSANILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPV 403
            |:|:|:::.  |.| ....|....||:||:|:|.|||.:.||||.|..|:.||.|||:||:.:|:
Human   333 QKVLWRFDG--NKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPL 395

  Fly   404 FADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESV 468
            |.|||.|...:.|.|..::|...|:...:...|:|.||.:|.|.:.:...|::..|:|:.|.:..
Human   396 FFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRA 460

  Fly   469 VYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIY-IIAALVLYIVFIINKI----VWKFVWRKLF 528
            |:|.|:|:.|.||.|::.....:.:...::||:. .:.|.|..::|||.|.    .|||
Human   461 VFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKF------ 519

  Fly   529 GKSNKVSKGKKVKK 542
                 ..||||.|:
Human   520 -----ARKGKKGKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_652627.2	GT1_Gtf-like	33..471	CDD:340817	121/456 (27%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	141/529 (27%)