DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	556	Identity:	154/556 - (27%)
Similarity:	270/556 - (48%)	Gaps:	76/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTV--------VSSVPPKVTHK 77
            |.|.|:|. .|..|:| ||.. ..||::....:::.|..||||:||        :....|..|
Zfish    16 LLLVTVPV-VESGNVL-VFPV-DVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYT-- 75

  Fly    78 SIN---------HIVVPMSAEDEKVLNDGMA-GMVKEKPSIWNTMKSIFSSLALL-IDKQV--DV 129
            |:|         ..:.|..:....:|.:|.. |.:|.:..:|.|      ||.:: |::::  ::
Zfish    76 SVNLKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQT------SLKMIEIEREMITNM 134

  Fly   130 LEDPRFQELYLNKGNKFDVV------FVGFFFNTYQVALGARFNCPVI--ISWSGPPMMMVNE-- 184
            :||.:..:..  |..|||::      :.|       |.||.....|::  :.|:     :..|
Zfish   135 IEDQQLMQSL--KKAKFDLILTDPAMYGG-------VMLGHYLKLPIVYNVRWT-----IFGEGH 185

  Fly   185 -VLGNPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFL-NHKYNKFYDRLWSKDKSM 247
             .:....||.||...:..|  ..|:|.:|::|....:.......|| ...||...:|....:.:
Zfish   186 FAIAPSPLSYVPVPMLEIP--DRMSFLERVKNVVMYIITETQIAFLIAPTYNALCERFIGPEVN- 247

  Fly   248 PTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVK-SKPDPLPEDIQEFLE-KGKHGAI 310
              |....:...|.......:.|.| ||.:|.::.:.|.|.| ||  |||:|:::|:: .|.||.|
Zfish   248 --FGNLVQEADLWLHRADFVFEYP-RPTMPNIVYMAGFQCKPSK--PLPQDLEDFVQSSGDHGVI 307

  Fly   311 LFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPK 375
            :.|||: |.|: :..:|.:.|.:..:.|.|::||:::. |.......|.|...|:||:|:|.|||
Zfish   308 VMSLGT-LIGQ-LPDDVAEAIAEAFAELPQKIIWRYKG-KRPSALGNNTLVMDWMPQNDLLGHPK 369

  Fly   376 LKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEV 440
            .:.|:.|.|..||.||.|||||::...:..|||.|..|:...|....:..||:|.:.|...:|||
Zfish   370 TRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEV 434

  Fly   441 IENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLD-IYII 504
            :.:|.|.:.::..|:|::|.|:.|.::.::|.|:|:||.||||:::....|.:.:.:::| |.::
Zfish   435 LYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVL 499

  Fly   505 AALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKV 540
            .:.|..|:..|..::..|..|...    :.:|.|:|
Zfish   500 ISAVSLIILSIYAVIRYFCCRICM----RTTKNKRV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	145/522 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	142/520 (27%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	148/542 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840