DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37D1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	565	Identity:	156/565 - (27%)
Similarity:	261/565 - (46%)	Gaps:	85/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVP-------PK 73
            |:|..|:|.|:....:..|||..:|  ..||:|....::.||.::||||||:  ||       .|
Zfish     3 LVVCFLSLLTVFSAGQCGNILVWYT--EGSHWINLKIVLDTLLDRGHNVTVL--VPDGALFMKAK 63

  Fly    74 VTHK-SINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLAL----LIDKQVD----- 128
            .:.: |..|..|..||:|.:...|.:.     :.|::....|.|..:.:    |..:..|
Zfish    64 ESDRFSYQHFSVSKSAQDMQDFFDELM-----RFSVFEMDNSSFLEIQMKFFNLGSQHQDMSLSY 123

  Fly   129 ---VLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPE 190
               :|:.|...: .|.|| |||||.....:....: :....|.|::.::..........:.|
Zfish   124 CDGILKSPELMD-KLKKG-KFDVVLSDPMYPCSDI-VAEELNVPLVYTFRFSVAHAAERMCG--- 182

  Fly   191 LSSVPQMHISAPPG----------QPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDK 245
                   .|.|||.          ..|:|.:|:.|....|..:.|:..:..:::.:|...:.:..
Zfish   183 -------QIPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDNYYTEYFGRST 240

  Fly   246 SMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGA 309
            |   :.:......:.....:...|.| ||.||....|||:.. :...|||:|::||:: .|..|.
Zfish   241 S---YCEMMGKADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDGI 300

  Fly   310 ILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPK-NTPGKSANILYKKWLPQDDILAH 373
            ::|:|||.:  :.:..|:...|...|:.:.|:|:|::...| :|.|::..|.  ||:||:|:|.|
Zfish   301 VVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIY--KWIPQNDLLGH 361

  Fly   374 PKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKA--- 435
            ||.:.||||.|..||.||.||||||:.:|:|.|||.|...:....       |.:.||..|:
Zfish   362 PKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRA-------AAVVVDSIKSMQP 419

  Fly   436 -----AIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIA 495
                 .:..||.:|.|.:.....|:::.|||:.|.:..|:|.|:|:|:.||.|::....::.:..
Zfish   420 QELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQ 484

  Fly   496 SNNLDIY----IIAALVLYIVFIINKIVWKFVWRKLFGKSNKVSK 536
            .:.||::    .:..|||||.|.:.|.   |:.|..|....|..|
Zfish   485 YHCLDVFAFLTTVLTLVLYICFKMAKF---FIMRCCFRSKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	144/530 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	145/528 (27%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	149/543 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910