DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	564	Identity:	157/564 - (27%)
Similarity:	273/564 - (48%)	Gaps:	69/564 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GGLLVALLALQTMPQGTEGANIL--GVFTSHSPSHFIVHMSIMKTLAEKGHNVTV-VSSVPPKVT 75
            |.|||.|| |..:..|..|..::  |.:     ||:....:|::.|.::.|:||| |.|..|.|.
Zfish     4 GALLVCLL-LCGVDVGWSGRVLVMPGEY-----SHWHNMRAIIEALVDRNHSVTVLVGSSSPTVP 62

  Fly    76 HKS---INHIVVPMSAEDEK---VLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPR 134
            |..   .::.|..::.|.|:   |.:|.:...:.|..:.:.|:.:||..::..:....:|.:. .
Zfish    63 HTQKARFDYHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVMSRFMTLTDEVCKG-M 126

  Fly   135 FQE--LYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELSSVPQM 197
            |:|  |.:.:.:.:||:|.........: :....|.|:::|...........:.|
Zfish   127 FKEDLLQMLRESHYDVLFSDPMMPCSDL-MAQTLNIPLVLSLRATFAYSFERMCG---------- 180

  Fly   198 HISAPPG------------QPMNFQQRMQN----FASTLGFNALNIFLNHKYNKFYDRLWSKDKS 246
            .:.|||.            ..|:|.:|::|    |:..:.|....:|.       :||::::.:.
Zfish   181 QMPAPPSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFT-------FDRIYTEIRG 238

  Fly   247 MP-TFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGA 309
            .| |..:......:.....:...|.| ||..|....:||:..| ...||.::::||:: .|.||.
Zfish   239 KPTTMCETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKEMEEFVQSSGDHGV 301

  Fly   310 ILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSA-NILYKKWLPQDDILAH 373
            ::|||||.:|  ::..|...||...|..:.|:|:|::..  .||...| |.....|:||:|:|.|
Zfish   302 VVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSG--KTPETLAPNTKIYDWIPQNDLLGH 362

  Fly   374 PKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIK 438
            ||.|.||||.|..|:.||.||||||:.||:|||||.|...:...|..:.|.:.||:..:...|:|
Zfish   363 PKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALK 427

  Fly   439 EVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYI 503
            .|:.||.|.:::...|:::.|:|:.|.:..|||.|:|:|:.||.|::.....:::...:.||
Zfish   428 TVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLD--- 489

  Fly   504 IAALVLYIVFIINKIVWK----FVWRKLFGKSNKVSKGKKVKKQ 543
            :||.:|.|..:|. .:|.    |::|:...|:....|.:|.|.:
Zfish   490 VAAFLLSIAALIT-FLWVKACCFLFRRCVRKTRPERKTQKSKNE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	141/516 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	143/516 (28%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	145/531 (27%)
		REC	<129..>178	CDD:302758	8/49 (16%)
		egt	<254..485	CDD:223071	86/236 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930