DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37D1 and ugt1a6

DIOPT Version :9

Sequence 1:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001107366.1	Gene:	ugt1a6 / 100135191	XenbaseID:	XB-GENE-5793241	Length:	531	Species:	Xenopus tropicalis

Alignment Length:	541	Identity:	152/541 - (28%)
Similarity:	253/541 - (46%)	Gaps:	92/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPP- 72
            :||:.||.|:      .:||  :|            ||::....::..||::||.:.|  ::|.
Frog    22 LGCADGGRLL------VVPQ--DG------------SHWLSMRVLVDRLAQRGHYIVV--AIPEV 64

  Fly    73 KVTHKSI-NHIVVPMSAEDEK-VLNDGMAGM---------VKEKPSIW-----NTMKSIFSSLAL 121
            .:..|.: |:.|...|:...| ||.:.|..|         :.||.:.|     |..:.:.|:...
Frog    65 NMLFKDLDNYKVKTFSSPYSKDVLENRMRRMNQEIFVDRILTEKITFWYESMSNATQWVVSACQH 129

  Fly   122 LIDKQVDVLEDPRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVL 186
            .:.....:.|        |.| ..||.:.....|...:: :....:.|.:       ..|...:.
Frog   130 FLQNSTLIRE--------LEK-EHFDAMLTDSVFPCGEI-VAEHLSIPSV-------SFMRGTIF 177

  Fly   187 GNPELSSVPQMHISAPPG----------QPMNFQQRMQNFASTLGFNALNIFLNHKYNKFY---- 237
            |..:::|    ...:||.          ..|:|.||::||.    .::|...:.|.:...|
Frog   178 GMDQIAS----QTPSPPSYVPRMFTVYTDNMSFSQRVKNFL----IHSLEHIVCHIFYYPYAQMA 234

  Fly   238 -DRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEF 301
             |.|..:..:|..|::    .|:.......:.|.| ||.:|.||.||||.. :|...||::.::.
Frog   235 SDFLKKEVTAMSLFSR----TSIWLMRYDFVFEFP-RPIMPNVILIGGINC-AKQKALPQEFEKL 293

  Fly   302 LE-KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWL 365
            :: .|:||.::||.||.:  ..|...:...|.:.|..:.|:|.|::.. |..|....|....|||
Frog   294 VKSSGEHGFVVFSFGSMV--SEIPMNIAMDIAEALRYIPQKVFWRYTG-KAPPNLGDNTHLVKWL 355

  Fly   366 PQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDV 430
            ||:|:|||||.:.||||||..||.|...:.|||:.||:..||..||.::.:.|.||.|.:..|..
Frog   356 PQNDLLAHPKARAFITHAGSHGVYEGICNAVPMVMLPLIGDQMDNAKRIESRGAGLILNVQNLIP 420

  Fly   431 DEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVH-MNFI 494
            |:...|:..||:||.|.:.::..|.|:||||:.|.:..|:|.|:|::|.||.|:: |..| :|:|
Frog   421 DDLSNAVMAVIDNPSYKENIQRLSSLHRDRPVQPLDLAVHWVEFVMKHKGAPHLR-PAAHDLNWI 484

  Fly   495 ASNNLDIY-IIAALVLYIVFI 514
            ...:||:. .:.|::|..:||
Frog   485 QYQSLDVMAFLLAVLLTTLFI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	145/521 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	144/505 (29%)
ugt1a6	NP_001107366.1	UDPGT	28..527	CDD:278624	149/535 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910