DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	534	Identity:	161/534 - (30%)
Similarity:	254/534 - (47%)	Gaps:	74/534 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGQT---GFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKK 66
            |.||   |||.|:|:   :.|.....|||....  ||:.....:.:.|:..||.:.::.| |:..
Mouse     7 AAQTLPAGFLFLVLW---ASVLGDKLLVVPQDG--SHWLSMKEIVEHLSERGHDIMVLVP-EVNL 65

  Fly    67 PIKNIKDVPAKSI-----LTSMQGRI-----------ANLLQSSKEPIIKQIINFHEMGIEITEL 115
            .:...|....|..     |..:|.|.           |:|:...:|.....|:  .:|.....:.
Mouse    66 LLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIV--VDMFFSNCQS 128

  Fly   116 LLKEPSVIELMKSNQTFDAVISE------VFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGS 174
            |||:.:.:..::.|: |||:.::      |.|       ||:...|.:.|......|....|..|
Mouse   129 LLKDSATLSFLRENK-FDALFTDPAMPCGVIL-------AEYLNLPSVYLFRGFPCSLEHMLGQS 185

  Fly   175 PSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKY------------- 226
            |||.||||....||||.|:..:|:.|  |:.  .|..||.|.    .||.||
Mouse   186 PSPVSYVPRFYTKFSDHMTFPQRLAN--FIV--NILENYLYY----CLYSKYEIIASDLLKRDVS 242

  Fly   227 FPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EH 290
            .|:..|:        :|.||.......:|||..||||.:||::. :|:..|.::...::..: ||
Mouse   243 LPSLHQN--------SLWLLRYDFVFEYPRPVMPNMIFLGGINC-KKKGKLTQEFEAYVNASGEH 298

  Fly   291 GVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAH 355
            |::.||:||.:..  :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|
Mouse   299 GIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGH 361

  Fly   356 DNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQ 420
            ....|||||.|.....|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::
Mouse   362 PKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALK 426

  Fly   421 KIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAML 485
            .:|||....:.:..:|..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:.
Mouse   427 TVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG 491

  Fly   486 ILYGGIIFVLYCIF 499
            .|...::.|::.:|
Mouse   492 FLLAIVLTVVFIVF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/368 (32%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	156/522 (30%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	152/511 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840695
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690