DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	547	Identity:	171/547 - (31%)
Similarity:	274/547 - (50%)	Gaps:	97/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FEL------KKPIKN-IKDVPAKSIL 80
            |..:::....|..::|...:|.|  |.....:.|||   ||:      |:.|:: |||.    :|
Mouse    35 NVKIIIDELLRKEHNVTVLVASG--ALFITPSSISPSLTFEIYPVPFGKEKIESVIKDF----VL 93

  Fly    81 TSMQGRIA-NLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVIELMKSNQTFDAVISEVFLNEA 144
            |.::.|.: :.:.:..:.:.|.|..||.:...|.:.:||...::..:: .:.|:.::|:
Mouse    94 TWLENRPSPSTIWTFYKEMAKVIEEFHLVSRGICDGVLKNEKLMSKLQ-KEKFEVLLSD------ 151

  Fly   145 HFGFAEHFKAPLIGLGTFGAISWNTDLVGS----------------PSPPSYVPSALLKFSDRMS 193
                      |:...|...|:......:.|                |.||||||:.|.:.:|:||
Mouse   152 ----------PVFPCGDIVALKLGIPFIYSLRFSPASTVEKHCGKVPFPPSYVPAILSELTDQMS 206

  Fly   194 LVERVGNQAFLTY---EYIFLNYFYLPRQEVLYRKYFPNNKQDFYD--MRKNTALV--------- 244
            ..:||.|  |::|   :|:|         |.|::::     ..:|.  :.:.|.|.
Mouse   207 FTDRVRN--FISYRMQDYMF---------ETLWKQW-----DSYYTKALGRPTTLCETMGKAEIW 255

  Fly   245 LLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIE-GAEHGVIYFSMGSNLKSKTLPL 308
            |:..:....|||||.||...|||:|. :..:||||::.||:: ..|||::.||:||.:|:  |..
Mouse   256 LMRTYWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVKN--LTD 317

  Fly   309 EKRQALIDTFAQLKQRVLWKFED--TDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTT 371
            ||...:....||:.|:|||:::.  .|..|....:|  ||.||:|:|.|....|||||||.....
Mouse   318 EKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLF--DWIPQNDLLGHPKTRAFITHGGTNGIY 380

  Fly   372 ESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMS 436
            |:|||..|.||:|:|.||..|:|..:..|..|.|:...::|:.||.|::.:||.|...:....:|
Mouse   381 EAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLS 445

  Fly   437 DRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLL 501
            ..:.||...||:|||:|:|.|.||||||:||.|:.||::.|||:||.       |.|:|.|:...
Mouse   446 RIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDV-------IGFLLACVASA 503

  Fly   502 IRLVWRLLQELFIKKDTSKPKQKAKRN 528
            |.||.:..  |||.:...|..:|.||:
Mouse   504 ILLVAKCC--LFIFQKVGKTGKKKKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	123/381 (32%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	167/533 (31%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	94/224 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840254
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690