DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	553	Identity:	163/553 - (29%)
Similarity:	264/553 - (47%)	Gaps:	66/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLLSC--VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTII----SP---------FE 63
            ||.|||.|  ...::..|::.....||:|...|:.:.|....|.||::    ||         |:
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYSHWHNMRAIIEALVDRNHSVTVLVSSSSPTVPHTQKARFD 70

  Fly    64 LKKPIKNIKDVPAKSILTSMQGRIANLLQSSKEP---IIKQIINFHEMGIEITELLLKEPSVIEL 125
            ......|:....||.|.:...........|..|.   |.:.:.||..:..::...||:...::::
Zfish    71 YHVFKVNMDKEEAKVIWSDFTHLWMKETDSKLERGFLIWRVMSNFRRLAADVCRSLLQNDDLLQM 135

  Fly   126 MKSNQTFDAVISEVFLNEAHFGFAEHFKAP-LIGLGTFGAISWNTDLVGSPSPPSYVPSALL--K 187
            :..:. :|.:.|:..:..:.. .|:....| :|.|....|.::.......|:||||||:..|  .
Zfish   136 LGESH-YDVLFSDPMMPCSDL-MAQTLNIPQVISLRLTFAYTFERMCGQMPAPPSYVPAVALTDH 198

  Fly   188 FSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYF-----PN------NKQDFYDMRKNT 241
            .:||||.:|||.|  .|.| :|....|.|.....:.|.|.     |.      .|.|.:
Zfish   199 LTDRMSFMERVEN--MLLY-FIHTTVFRLNTMLTVDRLYTEIRGKPTTMCETMGKADIW------ 254

  Fly   242 ALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKT 305
               |:..:....:|||:.||...|||:|. :..:||.|::.||::.: :|||:.||:||.:|:
Zfish   255 ---LIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEMEEFVQSSGDHGVVVFSLGSMIKN-- 313

  Fly   306 LPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLST 370
            |..|:...:.....|:.|:|:|::..........|..|.||.||:|:|.|....|||||||....
Zfish   314 LTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGL 378

  Fly   371 TESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDM 435
            .|:|||..|.||:|:|.||..|:...:..|..|.:....|.|..|:.|::.::|||...:.:..:
Zfish   379 YEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRL 443

  Fly   436 SDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLD--AMLILYGGIIFVLY-- 496
            |..:.||...||::||||:|.|.|:||||:||..:.:|::.|||.||  |.|:....:|..|:
Zfish   444 SRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWVK 508

  Fly   497 -CIFLLIRLVWRLLQELFIKKDTSKPKQKAKRN 528
             |.||..|.|.:           ::|::|.:::
Zfish   509 ACCFLFRRCVRK-----------TRPERKTQKS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	116/363 (32%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	155/515 (30%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	85/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860