DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	547	Identity:	168/547 - (30%)
Similarity:	267/547 - (48%)	Gaps:	53/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDV 74
            ||.:.|.|..|..|....||  .....||:.....:.:.|...||:||:::  .....:.|....
Human     9 FLLIQLSCYFSSGSCGKVLV--WPTEYSHWINMKTILEELVQRGHEVTVLT--SSASTLVNASKS 69

  Fly    75 PAKSILTSMQGRIANLLQSSKEPIIKQII------NFHEMGIEITEL---------------LLK 118
            .|..:.........|.|:.|...|:.:.|      .|.....::.||               :|.
Human    70 SAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLN 134

  Fly   119 EPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAP-LIGLGTFGAISWNTDLVGSPSPPSYVP 182
            :..:::|.:|.  ||.::::. ||......||.|..| |..|......::..:..|...||||||
Human   135 KKLMMKLQESK--FDVILADA-LNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVP 196

  Fly   183 SALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLN 247
            ..:.:.||:|..:||:.|...:.|...:...:.|.:.:..|.:........|..|.| ..:.|:.
Human   197 VVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGK-AEMWLIR 260

  Fly   248 QHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKR 311
            .:....||||:.||:..|||:|. :..:||||::.||::.: |:|::.||:||.:.:  :..|..
Human   261 TYWDFEFPRPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGIVVFSLGSMISN--MSEESA 322

  Fly   312 QALIDTFAQLKQRVLWKFEDTDLPGKPANVFISD-----WFPQDDILAHDNVLAFITHGGLLSTT 371
            ..:....||:.|:|||:|:     ||..|...|:     |.||:|:|.|....|||||||.....
Human   323 NMIASALAQIPQKVLWRFD-----GKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIY 382

  Fly   372 ESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMS 436
            |:|||..|.||||:|.||..|:|..:..|..::|....:||..||.|::.:||:|...:.|..:|
Human   383 EAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLS 447

  Fly   437 DRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLL 501
            ..:.||...||:|||:|:|.|.||||||:||.|:.:|.:||||:||.       |.|:|.|:..:
Human   448 RIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDV-------IAFLLACVATV 505

  Fly   502 IRLVWRLLQELFIKKDTSKPKQKAKRN 528
            |.::.:..  ||..:..:|..:|.||:
Human   506 IFIITKFC--LFCFRKLAKKGKKKKRD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	122/355 (34%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	162/521 (31%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	158/518 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150287
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690