Protein Alignment Ugt302C1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_652626.1
• Gene: Ugt302C1 / 53510
• FlyBaseID: FBgn0040259
• Length: 528
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 170/573 - (29%)
• Similarity: 269/573 - (46%)
• Gaps: 103/573 - (17%)

  Fly     8 TGFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTII-----------SP 61
            :..|.:.|.|..|..|....||  .....||:.....:...|...||:||::           ||
Human     7 SALLLIQLSCYFSSGSCGKVLV--WPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSP 69

  Fly    62 FELKKPIKNIKDVPAKSILTSMQGRIANLLQSSKEPIIKQII---------NFHEMGIEITELLL 117
            ..||..:..:                 :|.::..|.||||::         .|.....::.|::.
Human    70 STLKFEVYPV-----------------SLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMW 117

  Fly   118 KEPSVI-----------ELMKSNQ--TFDAVISE-VFLNEAHFG--FAEHFKAPLIGLGTFG--- 163
            ....::           :|||..|  .||.|::: ||    .||  .||..|.|.:....|.
Human   118 TFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVF----PFGELLAELLKIPFVYSLRFSPGY 178

  Fly   164 AISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYF- 227
            ||..::.  |...||||||..:.:.||:|:.:|||.|..::.|...:...|.:.:.:..|.:..
Human   179 AIEKHSG--GLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLG 241

  Fly   228 -PNN------KQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFI 285
             |..      |.|.:         |:..:....||.|..||:..|||:|. :..:||||::.||:
Human   242 RPTTLSETMAKADIW---------LIRNYWDFQFPHPLLPNVEFVGGLHC-KPAKPLPKEMEEFV 296

  Fly   286 EGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQ 349
            :.: |:||:.||:||.:.:.:  .|:...:....|::.|:|||:|:.........|..:..|.||
Human   297 QSSGENGVVVFSLGSMVSNTS--EERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQ 359

  Fly   350 DDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAK 414
            :|:|.|....|||||||.....|:|||..|.||:|:|.||..|:|..:..|..|::.:..:||..
Human   360 NDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTD 424

  Fly   415 LLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYH 479
            ||.|::.:||:|...:....:|..:.||...||:|||:|:|.|.||||||:||.|:.||.:.|||
Human   425 LLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYH 489

  Fly   480 NLDA---MLILYGGIIFVL-YCIFLLIRLVWRLLQELFIKKDTSKPKQKAKRN 528
            :||.   :|.....:||:: .|:|    .||:.::       |.|   |.||:
Human   490 SLDVTGFLLACVATVIFIITKCLF----CVWKFVR-------TGK---KGKRD 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	Glycosyltransferase_GTB-type	<185..507	CDD:471961	113/334 (34%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	162/550 (29%)