DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	544	Identity:	145/544 - (26%)
Similarity:	253/544 - (46%)	Gaps:	89/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLFCLLSCVS-AYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FELKKPIKNIKD 73
            |.||.||..:| .|...|::.....||:.....|.:.|...||.||::.|   :.:|      ::
Zfish     7 LCLFSLLCVLSGTYGGKVLVFPLDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWYIK------EE 65

  Fly    74 VPAKSILT---------SMQGRIANLLQSSKE-------------PIIKQIINFHEMGIEITELL 116
            .|..|.:|         ...|.:.|.|...|.             .|:.:....||..:::.:.:
Zfish    66 SPFYSSITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRM 130

  Fly   117 LKEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVG-------- 173
            |::..|:..:: :..||.|:::                |.:|.|...|..:|..||.
Zfish   131 LEDEKVMNSIQ-DAKFDVVLAD----------------PAVGGGPILAYKFNIPLVFNVRWTIQG 178

  Fly   174 ------SPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYF-PNNK 231
                  :|||.||:|...::.:|:||.::||.|........|.:.....|.......|:| ||
Zfish   179 EGHFAIAPSPLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPN-- 241

  Fly   232 QDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYF 295
            ..::.:.::..:.|:....:..||||..||::.:.|... :..:|||.|:.:|:|.: |||||..
Zfish   242 VTYFSLFQDADIWLMRNDFTFEFPRPTMPNIVYMSGFQC-KPAKPLPNDLEKFVESSGEHGVIVM 305

  Fly   296 SMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPA----NVFISDWFPQDDILAHD 356
            |:|:.:..  ||.:....:...||:|.|:|:|::...    :|.    |..:.:|.||:|:|.|.
Zfish   306 SLGTLIAQ--LPQDMTDDIAAAFAELPQKVIWRYTGP----RPVTLGNNTLLVEWLPQNDLLGHP 364

  Fly   357 NVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQK 421
            .:..|:.|||.....|:|||..|.:|:|:..||..|:.|.|..|....|....|.....|.|:::
Zfish   365 QIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKE 429

  Fly   422 IINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAML- 485
            ::.||...:.::.:|..:.||...||:||::|:|.|.|:|||.:||:.|..:::|:||::|.:|
Zfish   430 VLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILT 494

  Fly   486 ILYGGIIFVL----------YCIF 499
            ::..|.:|.|          .|:|
Zfish   495 LMVTGFVFALMIGYTIKYFCLCVF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	104/368 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	138/529 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584448
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690