DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	523	Identity:	154/523 - (29%)
Similarity:	243/523 - (46%)	Gaps:	67/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLL---SCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDVP 75
            |..|||   ....|...|||  ....||:.....:.:.|:..||:|.::.| |:...:...::..
Mouse    12 LRVCLLLAFGLAQAGRLLVV--PMDGSHWFSMKMIVEKLSHRGHEVVVVIP-EVSWHLGKSQNFT 73

  Fly    76 AKSILTSMQ---------------------GRIANLLQSSKEPIIKQIINFHEMGIEITELLLKE 119
            .|:...|..                     |..:.|..|.|        .|.::.......|..:
Mouse    74 VKTYSVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGK--------GFFQVLFSHCRSLFND 130

  Fly   120 PSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGL--GTF------GAISWNTDLVGSPS 176
            ..::|.:| .::||||..:.| :......|::|..|.:..  |.|      ||        ..||
Mouse   131 KKLVEYLK-QRSFDAVFLDPF-DVCGLTIAKYFSLPSVVFSGGIFCHYLDEGA--------QCPS 185

  Fly   177 PPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLP----RQEVLYRKYFPNNKQDFYDM 237
            ||||||..|.||:|.|:..|||.|......|..|..||:..    ..|||..   |....|.:
Mouse   186 PPSYVPRILSKFADTMTFKERVWNYFSYMKERAFCPYFFKTAIEIASEVLQT---PVTMTDLF-- 245

  Fly   238 RKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNL 301
             .:.::.:......|.||||..|||:.:||::.: ..:||.|:...::..: |||::.||:||.:
Mouse   246 -SSVSIWMFRTDFVLEFPRPVMPNMVYIGGINCH-PGKPLSKEFEAYVNASGEHGIVVFSLGSMV 308

  Fly   302 KSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGG 366
            ..  :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|
Mouse   309 SE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 371

  Fly   367 LLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQR 431
            .....|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::.:|||....:.
Mouse   372 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 436

  Fly   432 VRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLY 496
            :..:|..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:..|...::.|::
Mouse   437 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVF 501

  Fly   497 CIF 499
            .:|
Mouse   502 IVF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	117/361 (32%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	149/509 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840360
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690