DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	151/546 - (27%)
Similarity:	268/546 - (49%)	Gaps:	56/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIK-----N 70
            ||.||..|.:...|....|::.....||:.....:.:.|.|.|||..:::| |:...||     .
  Rat    10 LAGLLLLLYALPWAEGGKVLVFPMEGSHWLSMRDVVRELHARGHQAVVLAP-EVTVHIKEEDFFT 73

  Fly    71 IKDVPAKSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEITEL--------------LLKEPS 121
            ::..|   :..:.||....::::.|  ::.:..|:.:..:|.:|:              ||...|
  Rat    74 LQTYP---VPYTRQGFRQQMMRNIK--VVFETGNYVKTFLETSEILKNISTVLLRSCMNLLHNGS 133

  Fly   122 VIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALL 186
            :::.:.|: :||.|:::..: ......|::...|.:....:.....:::....|.|.||:|:.|.
  Rat   134 LLQHLNSS-SFDMVLTDPVI-PCGAVLAKYLGIPTVFFLRYIPCGIDSEATQCPKPSSYIPNLLT 196

  Fly   187 KFSDRMSLVERVGNQAF-LTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHV 250
            ..||.|:.::||.|..: |..:||.  :|...|.|.|..:.          :::..:||.:..|.
  Rat   197 MLSDHMTFLQRVKNMLYPLALKYIC--HFSFTRYESLASEL----------LQREVSLVEVLSHA 249

  Fly   251 SL---------SFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKT 305
            |:         .:|||..|||:.:||::...|: ||.::...::..: |||::.||:||.:..
  Rat   250 SVWLFRGDFVFDYPRPVMPNMVFIGGINCVIKK-PLSQEFEAYVNASGEHGIVVFSLGSMVSE-- 311

  Fly   306 LPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLST 370
            :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|....
  Rat   312 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGI 376

  Fly   371 TESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDM 435
            .|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::.:|||....:.:..:
  Rat   377 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 441

  Fly   436 SDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFL 500
            |..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:..|   :..||..:|:
  Rat   442 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL---LAIVLTVVFI 503

  Fly   501 LIRLVWRLLQELFIKKDTSKPKQKAK 526
            :.:......::.|..|...|...|:|
  Rat   504 VYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	106/359 (30%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	142/521 (27%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	89/251 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344047
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790