DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	580	Identity:	163/580 - (28%)
Similarity:	266/580 - (45%)	Gaps:	106/580 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPTAGQTGFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTII----SP 61
            :||:       .|:|..:.|...|.|.||:  ....||:.....:...|....|.||::    ||
Zfish     6 LKPS-------PLVLIFIFSFTHAGNVLVL--PGEYSHWQNMRNVVDELLNRNHTVTVLVCSASP 61

  Fly    62 --------------FELKKPIKNIKDVPAKSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEI 112
                          ||:....:.:.....:.|....|....|.||::               ::|
Zfish    62 TINFTQQERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTA---------------LQI 111

  Fly   113 TELL----LKEPSVIELMKSNQTFDAVIS----EVFLNEAHFGFAEHFKAPLIGLGTFGAISWNT 169
            .|||    :...::.:.|..|....|.:|    :|..|:..|..|: ..|.::||....::..:.
Zfish   112 IELLGRVRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMFMCAD-LLAEMLGLPLVLSVRISP 175

  Fly   170 D-----LVGS-PSPPSYVPSALLKFSDRMSLVERVGNQ--------AFLTYEYIFLNYFYLPRQE 220
            .     :.|. |:|||:||......:|||..:|||.|.        :|....:|.|:.:|   .:
Zfish   176 GFCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISLDSYY---TD 237

  Fly   221 VLYRKYFPN------NKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPK 279
            ||.:   |.      .|.|.:         |:..:....:|||:.||...|||:|. :..:||.|
Zfish   238 VLGK---PTTMCETMGKADIW---------LIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSK 289

  Fly   280 DILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFI 343
            ::.||::.: :|||:.||:||.:|:  |..|:...:.....|:.|:|:|::..........|..|
Zfish   290 EMEEFVQSSGDHGVVVFSLGSMIKN--LTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKI 352

  Fly   344 SDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYE 408
            .||.||:|:|.|....|||||||.....|:|||..|.||:|:|.||..|:...:..|..|.:...
Zfish   353 YDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDIN 417

  Fly   409 ELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDL 473
            .|.|..|:.|::.::|||...:.:..:|..:.||...||::||||:|.|.|:||||:||..:.:|
Zfish   418 TLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHEL 482

  Fly   474 NFIQYHNLD--AMLILYGGIIFVLY---CIFLLIRLVWRLLQELFIKKDTSKPKQKAKRN 528
            ::.|||.||  |.|:....:|..|:   |.||..|.|.:           ::|::|.:::
Zfish   483 SWYQYHCLDVAAFLLSIAALITFLWVKACCFLFRRCVRK-----------TRPERKTQKS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	116/373 (31%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	155/533 (29%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	85/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860