DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	565	Identity:	178/565 - (31%)
Similarity:	275/565 - (48%)	Gaps:	89/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFEL------KKPIK 69
            |.||:|.|.......:..||:.....||:.....|.:.|....|.||:::|.|.      .....
Mouse     6 LQLLIFHLTLAEIVLSGNVVVWPTDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAFI 70

  Fly    70 NIKDVP---AKSILTS-MQGRIANLLQSSKEPI-----IKQIIN----FHEMGIEITELLLKEPS 121
            |.:::|   .||.:.. ::..||..|.....|:     .|::.|    |:....::.:.:|..|:
Mouse    71 NFEEIPVSYTKSKIDEIIEHMIALWLDHRPTPLTMWTFYKELGNLLATFYTTNKQMCDGVLNNPT 135

  Fly   122 VIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGS------------ 174
            |:|.::.. .||.::::                |:...|...|:......|.:
Mouse   136 VMERLQKG-GFDVLLAD----------------PVTMCGELVALKLGIPFVYTLRFSPAFTVERH 183

  Fly   175 ----PSPPSYVPSALLKFSDRMSLVERVGNQAFLTY---EYIFLNY------FYLPRQEVLYRKY 226
                |:|.||||:||.:.:|:||..|||.|  .::|   :|||..|      :|   .:||.|
Mouse   184 CGKIPAPISYVPAALSELTDQMSFGERVKN--IISYSLQDYIFKTYWGEWNSYY---SKVLGR-- 241

  Fly   227 FPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIE-GAEH 290
             |..   ..:......:.|:..:....|||||.||...|||:|. :..:||||::.||:: ..||
Mouse   242 -PTT---LCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFVQTSGEH 301

  Fly   291 GVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFED--TDLPGKPANVFISDWFPQDDIL 353
            |::.||:||.:|:  |..||...:....||:.|:|||:::.  .|..|....:|  ||.||:|:|
Mouse   302 GIVVFSLGSMVKN--LTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLF--DWIPQNDLL 362

  Fly   354 AHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAA 418
            .|....|||||||.....|:|||..|.||:|:|.||..|:|..:..|..|.|:...::|:.||.|
Mouse   363 GHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNA 427

  Fly   419 IQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDA 483
            ::.:||.|...:....:|..:.||...||:|||:|:|.|.||||||:||.|:.||::.|||:||.
Mouse   428 LRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDV 492

  Fly   484 MLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAKRN 528
                   |.|:|.|:...|.||.:..  |||.:...|..:|.||:
Mouse   493 -------IGFLLACVASAILLVAKCC--LFIFQKVGKTGKKKKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	127/376 (34%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	169/535 (32%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	94/224 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840206
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790