DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and UGT1A3

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_061966.1	Gene:	UGT1A3 / 54659	HGNCID:	12535	Length:	534	Species:	Homo sapiens

Alignment Length:	520	Identity:	155/520 - (29%)
Similarity:	248/520 - (47%)	Gaps:	56/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYHVGSALAKGLAAAGHQVTIISPFELKKPIKN-------------IKDVPAKSILTSMQGRIA 88
            ||:.....:.:.|.|.|||..:::| |:...||.             .:|...:.:|...|
Human    39 SHWLSMREVLRELHARGHQAVVLTP-EVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQ---- 98

  Fly    89 NLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVIELMKS-------NQT-FDAVISEVFLNEAH 145
              |....|..:|:.  |..|.:.....|:...|.:||:.:       |.| ||.|:::. :|...
Human    99 --LYFETEHFLKKF--FRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDP-VNLCA 158

  Fly   146 FGFAEHFKAPLIGLGTFGAISWNTDLVGS--PSPPSYVPSALLKFSDRMSLVERVGNQAF-LTYE 207
            ...|::...|.:..  ...|..:.|..|:  |:|.||:|..|...||.|:.::||.|..: |...
Human   159 AVLAKYLSIPTVFF--LRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALS 221

  Fly   208 YIFLNYFYLP----RQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGM 268
            || .:.|..|    ..|:..|:.      ...|:..:.::.|......:.:|||..|||:.:||:
Human   222 YI-CHAFSAPYASLASELFQREV------SVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGI 279

  Fly   269 H-INRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFED 331
            : .|||  ||.::...:|..: |||::.||:||.:..  :|.:|..|:.|...::.|.|||::..
Human   280 NCANRK--PLSQEFEAYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTG 340

  Fly   332 TDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARA 396
            |.......|..:..|.||:|:|.|....|||||.|.....|||.:..|.|.:|:||||..|..|.
Human   341 TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRM 405

  Fly   397 EQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHK 461
            |..|.|||::..|::|..|..|::.:||:....:.:..:|..::|:...||:.||:|||.|.|||
Human   406 ETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK 470

  Fly   462 GAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            ||.:||.|:.||.:.|||:||.:..|...::.|.:..|......:|   :...||...|...|:|
Human   471 GAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR---KCLGKKGRVKKAHKSK 532

Fly 527 526
Human 533 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	116/365 (32%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	152/511 (30%)
UGT1A3	NP_061966.1	egt	<262..508	CDD:223071	93/249 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150603
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790