Protein Alignment Ugt302C1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_652626.1
• Gene: Ugt302C1 / 53510
• FlyBaseID: FBgn0040259
• Length: 528
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 153/541 - (28%)
• Similarity: 257/541 - (47%)
• Gaps: 52/541 - (9%)

  Fly    14 LLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP-----------FELKK- 66
            ||.|:|..|.::...::|.....||:.......:.|...||::.:::|           :.||.
Human    15 LLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTY 79

  Fly    67 PIKNIKDVPAKSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVI----ELMK 127
            |:...::...:|.::.......|      :..::::|..::...:.:.:||...|.:    |||.
Human    80 PVPFQREDVKESFVSLGHNVFEN------DSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMA 138

  Fly   128 S--NQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALLKFSD 190
            |  ..:||.::::.||..:.. .|::...|.:........|...:....|:|.||||..|...||
Human   139 SLAESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSD 202

  Fly   191 RMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKY------FPNNKQDFYDMRKNTALVLLNQH 249
            .|:.::||.|. .:.:...||       .:|:|..|      |...:....|:..:.::.|....
Human   203 HMTFLQRVKNM-LIAFSQNFL-------CDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSD 259

  Fly   250 VSLSFPRPYSPNMIEVGG---MHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEK 310
            ....:|||..|||:.|||   :|.|    ||.::...:|..: |||::.||:||.:..  :|.:|
Human   260 FVKDYPRPIMPNMVFVGGINCLHQN----PLSQEFEAYINASGEHGIVVFSLGSMVSE--IPEKK 318

  Fly   311 RQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIY 375
            ..|:.|...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|.....|||.
Human   319 AMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESIC 383

  Fly   376 HRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYR 440
            :..|.|.:|:||||..|..|.|..|.|||::..|::|..|..|::.:||:....:.:..:|..::
Human   384 NGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHK 448

  Fly   441 DQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLV 505
            |:...||:.||:|||.|.|||||.:||.|:.||.:.|||:||.:..|...::.|.:..|......
Human   449 DRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYG 513

  Fly   506 WRLLQELFIKKDTSKPKQKAK 526
            :|   :...||...|...|:|
Human   514 YR---KCLGKKGRVKKAHKSK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	Glycosyltransferase_GTB-type	<185..507	CDD:471961	109/331 (33%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	145/519 (28%)