DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	505	Identity:	153/505 - (30%)
Similarity:	245/505 - (48%)	Gaps:	50/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LAAAGHQVTIISPFELKKPIKNIK-------DVP------AKSILTSMQG--RIANLLQ--SSKE 96
            |.|.|||..:::| |:...||..|       .||      .:..|...||  ...:||:  |...
Human    51 LHARGHQAVVLTP-EVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSM 114

  Fly    97 PIIKQI-INFHEMGIEITELLLKEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLG 160
            .|:..: :..|...:|    ||...::|..:.:. :||.|:::. :|......|::...|.:...
Human   115 AIMNNVSLALHRCCVE----LLHNEALIRHLNAT-SFDVVLTDP-VNLCGAVLAKYLSIPAVFFW 173

  Fly   161 TFGAISWNTDLVGS--PSPPSYVPSALLKFSDRMSLVERVGNQAF-LTYEYIFLNYFYLP----R 218
            .:  |..:.|..|:  |:|.||:|..|...||.|:.::||.|..: |...|| .:.|..|    .
Human   174 RY--IPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYI-CHTFSAPYASLA 235

  Fly   219 QEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMH-INRKRQPLPKDIL 282
            .|:..|:.      ...|:....::.|......:.:|||..|||:.:||:: .|.|  ||.::..
Human   236 SELFQREV------SVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGK--PLSQEFE 292

  Fly   283 EFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDW 346
            .:|..: |||::.||:||.:..  :|.:|..|:.|...::.|.|||::..|.......|..:..|
Human   293 AYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 355

  Fly   347 FPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELS 411
            .||:|:|.|....|||||.|.....|||.:..|.|.:|:||||..|..|.|..|.|||::..|::
Human   356 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 420

  Fly   412 SAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFI 476
            |..|..|::.:||:....:.:..:|..::|:...||:.||:|||.|.|||||.:||.|:.||.:.
Human   421 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWY 485

  Fly   477 QYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            |||:||.:..|...::.|.:..|......:|   :...||...|...|:|
Human   486 QYHSLDVIGFLLAVVLTVAFITFKCCAYGYR---KCLGKKGRVKKAHKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	112/357 (31%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	150/496 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150602
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690