DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	530	Identity:	155/530 - (29%)
Similarity:	244/530 - (46%)	Gaps:	76/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYHVGSALAKGLAAAGHQVTIISP------FELKKPIKNIKDVP-------------------A 76
            ||:.....:.:.|:..||::.::.|      .|.|...:.|..||                   .
Human    37 SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAE 101

  Fly    77 KSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEI--TELLLKEPSVIELMKSNQTFDAVISE- 138
            :|.||:.|....|              |...:|:..  .:.||::...:...|.:: |||:.::
Human   102 RSFLTAPQTEYRN--------------NMIVIGLYFINCQSLLQDRDTLNFFKESK-FDALFTDP 151

  Fly   139 -----VFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERV 198
                 |.|       ||:...|.:.|......|.......||.|.||:|....||||.|:..:||
Human   152 ALPCGVIL-------AEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRV 209

  Fly   199 GN------QAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRP 257
            .|      :.:|.| .:|..|..| ...||.|..      |...:.:..::.||.....|.:|||
Human   210 ANFLVNLLEPYLFY-CLFSKYEEL-ASAVLKRDV------DIITLYQKVSVWLLRYDFVLEYPRP 266

  Fly   258 YSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQL 321
            ..|||:.:||::. :||:.|.::...:|..: |||::.||:||.:..  :|.:|..|:.|...::
Human   267 VMPNMVFIGGINC-KKRKDLSQEFEAYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKI 328

  Fly   322 KQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIF 386
            .|.|||::..|.......|..:..|.||:|:|.|....|||||.|.....|||.:..|.|.:|:|
Human   329 PQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 393

  Fly   387 GDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAV 451
            |||..|..|.|..|.|||::..|::|..|..|::.:||:....:.:..:|..::|:...||:.||
Human   394 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 458

  Fly   452 YWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKK 516
            :|||.|.|||||.:||.|:.||.:.|||:||.:..|...::.|.:..|......:|   :...||
Human   459 FWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR---KCLGKK 520

  Fly   517 DTSKPKQKAK 526
            ...|...|:|
Human   521 GRVKKAHKSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	117/361 (32%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	148/501 (30%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	152/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150653
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690