DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and UGT1A7

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_061950.2	Gene:	UGT1A7 / 54577	HGNCID:	12539	Length:	530	Species:	Homo sapiens

Alignment Length:	567	Identity:	171/567 - (30%)
Similarity:	265/567 - (46%)	Gaps:	87/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGQTGFLALLLFCLLSC--VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FEL 64
            ||.||.|.|.:..||:|  ..|...|||  ....||:....::.:.|...||:|.::.|   ::|
Human     4 AGWTGLLPLYVCLLLTCGFAKAGKLLVV--PMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQL 66

  Fly    65 KKPIK----------NIKD--------------VP---AKSILTSMQGRIANLLQSSKEPIIKQI 102
            .:.:.          .::|              .|   |.|:|||....|.:|..|:
Human    67 GRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSN-------- 123

  Fly   103 INFHEMGIEITELLLKEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAP--LIGLGTF--- 162
                      ...|..:..::|.:|.: .||||..:.| :......|::|..|  :...|.|
Human   124 ----------CRSLFNDRKLVEYLKES-CFDAVFLDPF-DACGLIVAKYFSLPSVVFARGIFCHY 176

  Fly   163 ---GAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLP----RQE 220
               ||        ..|:|.||||..||.|||.|:..|||.|......|::|..||:..    ..|
Human   177 LEEGA--------QCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASE 233

  Fly   221 VLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFI 285
            :|      ......||:..:|::.||.....|.:|:|..||||.:||::.::.: |:|.:...:|
Human   234 IL------QTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGK-PVPMEFEAYI 291

  Fly   286 EGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQ 349
            ..: |||::.||:||.:..  :|.:|..|:.|...::.|.|||::..|.......|..:..|.||
Human   292 NASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQ 354

  Fly   350 DDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAK 414
            :|:|.|....|||||.|.....|||.:..|.|.:|:||||..|..|.|..|.|||::..|::|..
Human   355 NDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSED 419

  Fly   415 LLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYH 479
            |..|::.:||:....:.:..:|..::|:...||:.||:|||.|.|||||.:||.|:.||.:.|||
Human   420 LENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYH 484

  Fly   480 NLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            :||.:..|...::.|.:..|......:|   :...||...|...|:|
Human   485 SLDVIGFLLAVVLTVAFITFKCCAYGYR---KCLGKKGRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	120/361 (33%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	158/536 (29%)
UGT1A7	NP_061950.2	egt	<264..504	CDD:223071	89/242 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150373
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690