Protein Alignment Ugt302C1 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_652626.1
• Gene: Ugt302C1 / 53510
• FlyBaseID: FBgn0040259
• Length: 528
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 159/536 - (29%)
• Similarity: 259/536 - (48%)
• Gaps: 27/536 - (5%)

  Fly     6 GQTGFLALLLFCLLSC--VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FELK 65
            |.|..:.|.:..||:|  ..|...|||  ....||:....::.:.|...||:|.::.|   ::|.
Human     5 GWTSPIPLCVSLLLTCGFAEAGKLLVV--PMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLG 67

  Fly    66 KPIK-NIKDVPAKSILTSMQGRIANLLQSSKEPIIKQIIN--------FHEMGIEITELLLKEPS 121
            |.:. .:|.......|..:.....:...:..:..::.:.:        |..:.......|..:..
Human    68 KSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRK 132

  Fly   122 VIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALL 186
            ::|.:|.: :||||..:.| :......|::|..|.:......|..:..:....|:|.||||..||
Human   133 LVEYLKES-SFDAVFLDPF-DACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILL 195

  Fly   187 KFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVS 251
            .|||.|:..|||.|......|::|..||.....|:  ...........||:..:|::.||.....
Human   196 GFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEI--ASEILQTPVTAYDLYSHTSIWLLRTDFV 258

  Fly   252 LSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALI 315
            |.:|:|..||||.:||::.::.: |||.:...:|..: |||::.||:||.:..  :|.:|..|:.
Human   259 LDYPKPVMPNMIFIGGINCHQGK-PLPMEFEAYINASGEHGIVVFSLGSMVSE--IPEKKAMAIA 320

  Fly   316 DTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPF 380
            |...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|.....|||.:..|.
Human   321 DALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPM 385

  Fly   381 VGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQT 445
            |.:|:||||..|..|.|..|.|||::..|::|..|..|::.:||:....:.:..:|..::|:...
Human   386 VMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE 450

  Fly   446 PLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQ 510
            ||:.||:|||.|.|||||.:||.|:.||.:.|||:||.:..|...::.|.:..|......:|
Human   451 PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR--- 512

  Fly   511 ELFIKKDTSKPKQKAK 526
            :...||...|...|:|
Human   513 KCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	Glycosyltransferase_GTB-type	<185..507	CDD:471961	113/322 (35%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	149/506 (29%)