DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	169/526 - (32%)
Similarity:	257/526 - (48%)	Gaps:	68/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYHVGSALAKGLAAAGHQVTIISP-----FELKKPIK-NIKDVPAKSILTSMQGRIANLLQSSK 95
            ||:.....:...|...||:|.::.|     :|:.|... ..:..|:...:..::....:.:..|.
  Rat    34 SHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVDKTSAIEFESFPSSYSIADVEVIFMDCVNESI 98

  Fly    96 EPIIKQ--------IINFHEMGIEITELLLKEPSV-IELMK--SNQTFDAVISEVFLNEAHFGFA 149
            ..:.||        :....|...:.:|.|.::.:. .|||.  .|..||.::::.|...... .|
  Rat    99 YELPKQSFWGYFLMLQKLFERTSDYSERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDL-LA 162

  Fly   150 EHFKAPLI-GLGTFGAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAF-LTYEYIF-- 210
            |..|.||: .|..|...::.....|.|.||||||.|:.:.||||:.||||.:..: |.:::.|
  Rat   163 EILKIPLVYSLRFFPGSTYEKYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQV 227

  Fly   211 -----LNYFYLPRQEVLYRKYFPNN------KQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIE 264
                 .|..|   .|||.|   |..      |.|.:         |:..:..|.||.|..||...
  Rat   228 FDEKKWNELY---TEVLGR---PTTLSETMAKADIW---------LIRTYWDLEFPHPVLPNFDF 277

  Fly   265 VGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDT-FAQLKQRVLW 327
            |||:|. |..:||||:|.:|::.: ||||:.||:||.:.|.|   |:|..:|.. .||:.|:|||
  Rat   278 VGGLHC-RPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVGSLT---EERANVIAAGLAQIPQKVLW 338

  Fly   328 KFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLN 392
            :||........:|..:..|.||:|:|.|....|||||||.....|:|||..|.||||:||||..|
  Rat   339 RFEGKKPETLGSNTRLYKWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDN 403

  Fly   393 MARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHV 457
            :...:..|..|.:.:..:||..||.|::.:.|:|...:....:|..:.||...||:|||:|:|.|
  Rat   404 IVHLKTKGAAVRLDFLTMSSTDLLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFV 468

  Fly   458 SRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLY-----CIFLLIRLVWRLLQELFIKKD 517
            .||||||:||.|..||:::|||:||.:..|...::.|::     |:|..         :.|.|..
  Rat   469 MRHKGAKHLRVAGHDLSWVQYHSLDVIGFLLACVVTVMFILKKCCLFCC---------QKFTKAG 524

  Fly   518 TSKPKQ 523
            ..|.|:
  Rat   525 RKKKKE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	135/368 (37%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	167/521 (32%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	101/241 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344101
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690