DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	161/516 - (31%)
Similarity:	282/516 - (54%)	Gaps:	28/516 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLL---SCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDVP 75
            |..|||   ....|.|.|.:......|.:.|...|.:.||..||.||:|:|..:...|:.::.:.
  Fly    10 LSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRHIR 74

  Fly    76 AKSILTSMQGRIANLLQSSKEPIIKQIIN-FHEMGIEITEL------LLKEPSVIELM-KSNQTF 132
                :..:..||..:|:|  :.::..:|| :.|..:....|      :|.:|.|..:: ..:::|
  Fly    75 ----VAQLNERIKEMLES--DQVLDFMINKWTESALTAKALFNASNDILSDPGVQRMLHDKSESF 133

  Fly   133 DAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNT-DLVGSPSPPSYVPSALLKFSDRMSLVE 196
            |.:|.|....:|.:|..|.:.|.|:||.:. .|:|:| :|.|:|:|..|.|.:.:.||...||..
  Fly   134 DLIIMEPSSLDALYGLVEFYNATLMGLSSI-RINWHTYELAGNPAPSIYEPISPVGFSLETSLFS 197

  Fly   197 RVGNQAFLTYEYIFLNYFYL-PRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSP 260
            ||.|...:..|.: :||..| |.|..|::|:|..:.|...::|...:|:|:|.|.|:...|..:|
  Fly   198 RVYNWIHIMEEKL-VNYLILRPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAP 261

  Fly   261 NMIEVGGMHINRKRQPLPKDILEFIEGAEHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRV 325
            |:|||||:|::...:|..:::.:|::.|:|||||||||:::..|.||...::.|:.|||.|.:.:
  Fly   262 NIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESI 326

  Fly   326 LWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQF 390
            :||.|...:|.|..||::.:..||..||.|.||..|||:|||||..|::....|.:|:|:|.|||
  Fly   327 IWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQF 391

  Fly   391 LNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVE 455
            .||...:.:|....:....|:...|...|:.::.|.....:.:::|..::|:..:||:.||:|.|
  Fly   392 GNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTE 456

  Fly   456 HVSRHKGAKYLRSASQDLNFIQYHNLDAML-------ILYGGIIFVLYCIFLLIRLVWRLL 509
            :..|::....:|...:::..|:|:.:|::|       ::...:||::|.:||..|:..|.|
  Fly   457 YALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYTLFLKYRIRLRRL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	121/351 (34%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	144/448 (32%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	149/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445625
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800