DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	235/530 - (44%)
Similarity:	321/530 - (60%)	Gaps:	35/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDV- 74
            :..||..|.:.:.|...|.:......|.|.......|.||..|||||.::.|..|||:.|.:||
  Fly     6 IGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVF 70

  Fly    75 ------PAKSILTSMQGRIANLLQSSKEPIIKQIINF-HEMGIEITELLLKEPSVIE--LMKSNQ 130
                  ..|.::..:.|.: ||.|.:         || ::..:.:|..:|....|.|  |.....
  Fly    71 IPDVFNNYKELINELSGPM-NLWQEN---------NFINKFFVSVTRCVLTNKEVTETLLPPGKD 125

  Fly   131 TFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTD-LVGSPSPPSYVPSALLKFSDRMSL 194
            .||.:|.|...::|::|||.||.||:||:.|||. .||.| |||:.||.||.|.|....:|||:.
  Fly   126 HFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGT-DWNIDALVGNESPLSYTPLATGGLTDRMTF 189

  Fly   195 VERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFP--NNKQDFYDMRKNTALVLLNQHVSLSFPRP 257
            :||:.|....|..::...:.::..||.:|.||||  :.:....|:.:|.:|||||||.|||||||
  Fly   190 LERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRP 254

  Fly   258 YSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQL 321
            |.||||||||:||:.|..|||||:.|||:|: ||||||||:|||:.||.||.:::..::.|||.|
  Fly   255 YVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASL 319

  Fly   322 KQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIF 386
            .|||||||||..|||||:|||||.||||.|||||..|..||||||||||.|||:|.||.:|:|.|
  Fly   320 PQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFF 384

  Fly   387 GDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAV 451
            .|||||:.||.|.|:|:.:.:..::..:|...|:.::..|...|..|.||:|||||..:||:.|:
  Fly   385 YDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAI 449

  Fly   452 YWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKK 516
            :|.|:|.|||||.::|.|.|||.|..||:||.:.:|.||.:       ||:.::..:|.:|   .
  Fly   450 WWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGAL-------LLVAIIVGVLGKL---T 504

  Fly   517 DTSKPKQKAK 526
            |....|:|.|
  Fly   505 DFGNAKKKLK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	184/354 (52%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	214/468 (46%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	194/422 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445607
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800