DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	556	Identity:	167/556 - (30%)
Similarity:	270/556 - (48%)	Gaps:	70/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTAGQTGFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKP 67
            |..|...||     ||.|..|.....|::.....||:.....|.:.:::.||::.::
Zfish    18 PALGLFAFL-----CLFSSESVQAGKVLVMPVDGSHWLSMKILVEEMSSRGHEMVVL-------- 69

  Fly    68 IKNIKDVPAKSILTSMQGRI---------------ANLLQSSKEPIIK------------QIINF 105
                  ||..|||....|..               |::....|..|.|            .:|.|
Zfish    70 ------VPETSILIGKSGNFTTKSFRVPYSFDELNAHVDHIRKTAIEKAPRFIDIVGALGNLIQF 128

  Fly   106 HEMGIEITE-LLLKEPSVIELMKS--NQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISW 167
            ..|.::..| ||..||    ||||  :..|||::::.|| ......|::|..|.:..  ...|..
Zfish   129 TNMQVKACEGLLYDEP----LMKSLRDMKFDALLTDPFL-PCGSVIADYFSIPAVYF--LRGIPC 186

  Fly   168 NTDLVGS--PSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNN 230
            ..|...:  |||||::|.....::|:|:..:|:.|.....:|....:..:....|:..|  :...
Zfish   187 RLDEAAAQCPSPPSFIPRFFTGYTDKMTFPQRMINTFMTVFEKYLCHQLFASFDELATR--YLKK 249

  Fly   231 KQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIY 294
            ...:.::..:.|:.||....|..:|:|..|||:::||::. .||.||.|::.||:.|: |||.:.
Zfish   250 DTSYAELLGHGAVWLLRYDFSFEYPKPQMPNMVQIGGINC-AKRAPLTKELEEFVNGSGEHGFVV 313

  Fly   295 FSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVL 359
            |::||.:..  ||..|.:...:.|.|:.|||||::........|.||.:..|.||:|:|.|..|.
Zfish   314 FTLGSMVSQ--LPEAKAREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKWLPQNDLLGHPKVR 376

  Fly   360 AFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIIN 424
            ||:||||.....|.|.:..|.|.:|:||||..|..|....|...::...:::|.|||.|::|:||
Zfish   377 AFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVIN 441

  Fly   425 NPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYG 489
            :....:::..:|..:||:...||:.||:|.|.|.|||||::||.|:.|||:||||:||.:..|
Zfish   442 DKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWIQYHSLDVIGFL-- 504

  Fly   490 GIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKA 525
             ::.:|..||:.::......::.|.|   |:.|:||
Zfish   505 -LLILLTVIFVTVKSCMFCFRKCFKK---SQKKKKA 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	115/353 (33%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	153/515 (30%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	94/239 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760