DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	519	Identity:	159/519 - (30%)
Similarity:	246/519 - (47%)	Gaps:	58/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLL---SCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FELKKPI---- 68
            |..|||   ....|...|||  ....||:.....:.:.|...||:|.::.|   ::|.||:
Mouse    12 LCVCLLLASGLAQAGRLLVV--PMDGSHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNFVV 74

  Fly    69 ----------------KNIKDVPAKSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEITELLL 117
                            |...|...||   ..:|.|..||.|..:       .|.|:.......|.
Mouse    75 KTYAVSHTQEDLNREFKIFIDAQWKS---QQEGGILPLLDSPAK-------GFFELLFSHCRSLF 129

  Fly   118 KEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAP--LIGLGTFGAISWNTDLVGSPSPPSY 180
            .:..::|.:|.. :||||..:.| :......|::|..|  :...|.|  ..:..|....||||||
Mouse   130 NDKKLVEYLKQT-SFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIF--CHYLEDAAQCPSPPSY 190

  Fly   181 VPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLP----RQEVLYRKYFPNNKQDFYDMRKNT 241
            :|..||||:|.|:..||..|......|..|.:.|:..    ..|||..   |....|.:   ...
Mouse   191 IPRMLLKFTDTMTFKERTRNLLAYMGERAFCHKFFKSAADIASEVLQT---PVTMTDLF---SPV 249

  Fly   242 ALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKT 305
            ::.||.....|.||||..||:|.:||::.::.: ||.|:...::..: |||::.||:||.:..
Mouse   250 SIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGK-PLSKEFEAYVNASGEHGIVVFSLGSMVSE-- 311

  Fly   306 LPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLST 370
            :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|....
Mouse   312 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 376

  Fly   371 TESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDM 435
            .|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::.:|||....:.:..:
Mouse   377 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 441

  Fly   436 SDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIF 499
            |..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:..|...::.|::.:|
Mouse   442 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	116/355 (33%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	154/505 (30%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	96/286 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840694
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136043
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.690