DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt2b10

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001178605.1	Gene:	Ugt2b10 / 305264	RGDID:	1309989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	175/527 - (33%)
Similarity:	263/527 - (49%)	Gaps:	67/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYHVGSALAKGLAAAGHQVTIISP-FELKKPIKNIKDV-----PAKSILTSMQGRIANLLQSSK 95
            ||:.....:...|...||:||::.| ..|...:.|...:     |....||.:.......|:...
  Rat    36 SHWLNLRVILDELLKKGHEVTVLRPSASLSYEVDNTSAIEFETYPTSYSLTEVDEFFWESLRKYI 100

  Fly    96 EPIIKQ-----IINFHEM---GIEITELLLKEPSVI---ELMK--SNQTFDAVISEVFLNEAHFG 147
            ..:.||     .:.|.|:   ..:..|.|.|:  |:   |||.  .|..||.::::.|:.....
  Rat   101 YELPKQSFWGYFLMFQELVWVDSDYFESLCKD--VVFNKELMTKLQNSGFDVILADPFIPCGDL- 162

  Fly   148 FAEHFKAPLI-GLGTFGAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAF-LTYEYIF 210
            .||..|.||: .|..|...::.....|.|.||||||.|:.:.||||:.|||:.:..: |.:::.|
  Rat   163 LAEILKIPLVYSLRFFPGSTYEKYSGGLPMPPSYVPIAMSELSDRMTFVERMKHMIYVLCFDFWF 227

  Fly   211 -------LNYFYLPRQEVLYRKYFPNN------KQDFYDMRKNTALVLLNQHVSLSFPRPYSPNM 262
                   .|..|   .|||.|   |..      |.|.:         |:..:..|.||.|..||.
  Rat   228 QAFNEKKWNELY---TEVLGR---PTTLSETMAKADIW---------LIRTYWDLEFPHPVLPNF 277

  Fly   263 IEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDT-FAQLKQRV 325
            ..|||:|. |..:||||:|.:|::.: ||||:.||:||.:.:.|   |:|..:|.. .||:.|:|
  Rat   278 DFVGGLHC-RPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVGNLT---EERANVIAAGLAQIPQKV 338

  Fly   326 LWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQF 390
            ||:||........:|..:..|.||:|:|.|....|||||||.....|:|||..|.||||:||||:
  Rat   339 LWRFEGKKPETLGSNTRLYKWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQY 403

  Fly   391 LNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVE 455
            .|:...:..|..|.:.:..:||..|..|::.|.|:|...:....:|..:.||...||:|||:|:|
  Rat   404 DNIVHLKTKGAAVRLDFLTMSSTDLFTALKTITNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIE 468

  Fly   456 HVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSK 520
            .|.||||||:||.|:.||:::|||:||.       |.|:|.|:..::.::.:..  ||..:..:|
  Rat   469 FVMRHKGAKHLRVAAHDLSWVQYHSLDV-------IGFLLACVVTVMFILKKCC--LFCCQKFTK 524

  Fly   521 PKQKAKR 527
            ..:|.||
  Rat   525 AGRKKKR 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	135/370 (36%)
Ugt2b10	NP_001178605.1	UDPGT	26..529	CDD:278624	172/523 (33%)
Ugt2b10	NP_001178605.1	egt	35..510	CDD:223071	169/502 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830