DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	162/549 - (29%)
Similarity:	254/549 - (46%)	Gaps:	65/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP---FELKKPIK-NI 71
            |.:.||.......|...|||  ....||:.....:.:.|:..||:|.::.|   :.:.|.:. .:
  Rat    12 LCVCLFLASGFAQAGRLLVV--PMDGSHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTV 74

  Fly    72 KDVPAKSIL----------------TSMQGRIANLLQSSKEPIIKQIINFHEMGIEITELLLKEP 120
            |.......|                |...|..:.|..|.|        .|.|:.......|.|:.
  Rat    75 KTYSVSYTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGK--------GFFELLFSHCRSLFKDK 131

  Fly   121 SVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGL--GTF------GAISWNTDLVGSPSP 177
            .::|.:|.: :||||..:.| :......|::|..|.:..  |.|      ||        ..|||
  Rat   132 KLVEYLKQS-SFDAVFLDPF-DVCGLILAKYFSLPSVVFSGGIFCHYLDEGA--------QCPSP 186

  Fly   178 PSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLP----RQEVLYRKYFPNNKQDFYDMR 238
            |||||..|.||:|.|:..|||.|......|..|..||:..    ..|||..   |...:|.:
  Rat   187 PSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQT---PVTMRDLF--- 245

  Fly   239 KNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLK 302
            ...::.:......|.||||..|||:.:||::.::.: ||.|:...::..: |||::.||:||.:.
  Rat   246 SPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGK-PLSKEFEAYVNASGEHGIVVFSLGSMVS 309

  Fly   303 SKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGL 367
            .  :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|.
  Rat   310 E--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGS 372

  Fly   368 LSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRV 432
            ....|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::.:|||....:.:
  Rat   373 HGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENI 437

  Fly   433 RDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYC 497
            ..:|..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:..|   :..||..
  Rat   438 MRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL---LAIVLTV 499

  Fly   498 IFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            :|::.:......::.|..|...|...|:|
  Rat   500 VFIVYKSCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/361 (33%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	155/526 (29%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	88/246 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860