DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	164/539 - (30%)
Similarity:	272/539 - (50%)	Gaps:	66/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPTAGQTGFLALLLFCLL---SCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTII--S 60
            ||.|   :.||.:.|.|..   :|..     |::.....||:.....:...||..||:||::  |
  Rat     3 MKQT---SVFLLIQLICYFRPGACGK-----VLVWPTEYSHWINIKIILNELAQRGHEVTVLVSS 59

  Fly    61 PFELKKPIK------NIKDVP-AKSILTSMQGRIANLLQSSKEPI--------IKQIINFHEMGI 110
            ...|.:|.|      .|..|| :||.|.....:..:......|.:        ::::.|.:...:
  Rat    60 ASILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVV 124

  Fly   111 E-ITELLLKEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTF----------GA 164
            | :.:.|:...|:::.::.:| ||.::::. :.......||..|.||:....|          |
  Rat   125 ENLCKALIWNKSLMKKLQGSQ-FDVILADA-VGPCGELLAELLKTPLVYSLRFCPGYRCEKFSG- 186

  Fly   165 ISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPN 229
                    |.|.||||||..|.:.||||:.||||.|.    .:.::.::::.|.:|..:.:::.:
  Rat   187 --------GLPLPPSYVPVVLSELSDRMTFVERVKNM----LQMLYFDFWFQPFKEKSWSQFYSD 239

  Fly   230 ---NKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EH 290
               ......:|.....:.|:.....|.||.|:.||...|||:|. :..:|||:::.||::.: ||
  Rat   240 VLGRPTTLTEMMGKADIWLIRTFWDLEFPHPFLPNFDFVGGLHC-KPAKPLPREMEEFVQSSGEH 303

  Fly   291 GVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAH 355
            ||:.||:||.:|:  |..||...:....||:.|:|:|:|:........:|..:..|.||:|:|.|
  Rat   304 GVVVFSLGSMVKN--LTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGH 366

  Fly   356 DNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQ 420
            ....||:.|||.....|:|||..|.||||:|.||..|:......|..|.|.:..||:..||.|::
  Rat   367 PKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALK 431

  Fly   421 KIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDA-- 483
            .::|:|...:....:|..:.||...||:|||:|:|:|.||||||:|||...||::.|||:||.
  Rat   432 IVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIG 496

  Fly   484 -MLILYGGIIFVL--YCIF 499
             :|:...|::|::  :|:|
  Rat   497 FLLLCVVGVVFIITKFCLF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/362 (33%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	156/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760