DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	160/550 - (29%)
Similarity:	254/550 - (46%)	Gaps:	77/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ALLLFCLLSCVSAYNY-LVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFEL------KKPIK 69
            ||||..:..|..:.|. .|::.....||:.....:...|...||:||::.|...      |.|..
  Rat     8 ALLLLQISCCFQSGNCGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDL 72

  Fly    70 NIKDVPAKSILTSMQGRIANLLQ-----------SSKEPIIKQIIN-FHEMGIEITELLLKEPSV 122
            ..:..|.......::.....|:.           .|..|:::.:|: |.:..:.:.:..:....:
  Rat    73 KFETFPTSVSKDELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQL 137

  Fly   123 IELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGA----ISWNTDLVGSPS------- 176
            :..::.:: ||.::|:                |:...|...|    |.:...|..||.
  Rat   138 MAKLQESK-FDVLLSD----------------PVAACGELIAEVLHIPFLYSLRFSPGYKIEKSS 185

  Fly   177 -----PPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYD 236
                 ||||||..|......|:.::||.|.....|...:.:.|...:.:..|.:.. .......:
  Rat   186 GRFILPPSYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKKWDPFYSEIL-GRPTTLAE 249

  Fly   237 MRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSN 300
            ......:.|:..:..|.||.|..||:..:||:.. |..:|||||:.:|::.: ||||:.||:||.
  Rat   250 TMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQC-RPPKPLPKDMEDFVQSSGEHGVVVFSLGSM 313

  Fly   301 LKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGK-PA----NVFISDWFPQDDILAHDNVLA 360
            :.|.|  .||..|:....||:.|:|||||:     || ||    |..:..|.||:|:|.|....|
  Rat   314 VSSMT--EEKANAIAWALAQIPQKVLWKFD-----GKTPATLGPNTRVYKWLPQNDLLGHPKTKA 371

  Fly   361 FITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINN 425
            |:||||.....|:|||..|.||||:||:|..|:|.....|..||::...:|.:.|..|:::||||
  Rat   372 FVTHGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINN 436

  Fly   426 PEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGG 490
            |...:....:|..:.||...||::||:|:|.|.||||||:||....:|.:.|||:||.
  Rat   437 PFYKKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDV------- 494

  Fly   491 IIFVLYC---IFLLIRLVWRLLQELFIKKD 517
            |.|:|.|   |.:|....:..:..||:||:
  Rat   495 IGFLLTCSAVIAVLTVKSFLFIYRLFVKKE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	119/370 (32%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	154/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344103
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690