DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	561	Identity:	170/561 - (30%)
Similarity:	265/561 - (47%)	Gaps:	94/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLALLLFCLLSCV--SAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPF------ELKK 66
            :::.||...:||.  ||....|::.....||:.....:...|...||:||::.|.      ..|.
Mouse     5 WISALLLLQISCCFRSAKCGKVLVWPVDYSHWMNIKIILDELKQKGHEVTVLRPSTSIFLDPKKS 69

  Fly    67 PIKNIKDVPAKSILTSMQGRIANLLQS----------------SKEPIIKQIINFHEMGIEITEL 115
            |....:..|     ||....:..::.:                |..|:::.|  |.|.......|
Mouse    70 PGLKFETFP-----TSFSNDVMEIIFAKAVERWTYEVPRDTCLSYSPLLQNI--FDEYSDYCLTL 127

  Fly   116 LLKEPSVIELMKSNQ--TFDAVISEVF---------LNEAHFGFAEHFKAPLIGLGTFGAISWNT 169
            .....|..:||...|  .||.::|:..         |.:..|.::..| :|...|..:..
Mouse   128 CKDTVSNKQLMAKLQESKFDVILSDAIGPCGELIAELLQIPFLYSLRF-SPGYYLEKYSG----- 186

  Fly   170 DLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQD- 233
               |.|.||||||..|...|.:|:..|||.|...:.|    .::::         :.|...|.|
Mouse   187 ---GLPLPPSYVPVILSGLSGQMTFKERVKNMICMLY----FDFWF---------QTFREKKWDQ 235

  Fly   234 FYD--MRKNTALV---------LLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEG 287
            ||.  :.:.|.|:         |:..:..|.||.|..||:..|||:|. :..:||||::.:|::.
Mouse   236 FYSETLGRPTTLIETMGKAEMWLIRSYWDLEFPHPTLPNVYYVGGVHC-KPAKPLPKEMEDFVQS 299

  Fly   288 A-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGK-PA----NVFISDW 346
            : ||||:.||:||.:.:.|  .||..|:....||:.|:|||:|:     || ||    |..|..|
Mouse   300 SGEHGVVVFSLGSMVSNMT--EEKANAIAWALAQIPQKVLWRFD-----GKTPATLGPNTRIYKW 357

  Fly   347 FPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELS 411
            .||:|:|.|....|||||||.....|:|:|..|.:|||:||:|..|:|.....|..||::...:|
Mouse   358 LPQNDLLGHPKTKAFITHGGANGLYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMS 422

  Fly   412 SAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFI 476
            .:.||.|::::|:||...:....:|..:.||...||:|||:|:|.|.||||||:||..:.:|.:.
Mouse   423 RSDLLNALEEVIDNPFYKENAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWY 487

  Fly   477 QYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKD 517
            |||:||.:..|...:.|::..|......|:|    .|:||:
Mouse   488 QYHSLDVIGFLLAFVTFIVALIVKCFLFVYR----FFVKKE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	128/377 (34%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	164/534 (31%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	164/542 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840471
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690