DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	564	Identity:	160/564 - (28%)
Similarity:	262/564 - (46%)	Gaps:	87/564 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLALLLFCLLSCV--SAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFEL------KK 66
            :::.||...:||.  |.....|::.....||:.....:...|...||:||::.|...      |.
Mouse     5 WISALLLLQISCCFRSVKCGKVLVWPMEFSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKS 69

  Fly    67 PIKNIKDVPAKSILTSMQGRIANLLQ-----------SSKEPIIKQIIN-FHEMGIEITELLLKE 119
            |....:..|......:::......:.           .|..|:::.:|: |.:..:.:.:.::..
Mouse    70 PGLKFETFPTSVSKDNLENFFIKFVDVWTYEMPRDTCLSYSPLLQNMIDEFSDYFLSLCKDVVSN 134

  Fly   120 PSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPS-------- 176
            ..::..::.:: ||.::|:...:.... .||..:.|.:....|           ||.
Mouse   135 KELMTKLQESK-FDVLLSDPVASCGEL-IAELLQIPFLYSIRF-----------SPGYQIEKSSG 186

  Fly   177 ----PPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDM 237
                ||||||..|.....:|:.:||:.|...:.|...:...|...:.:..|.:|          :
Mouse   187 RFLLPPSYVPVILSGLGGQMTFIERIKNMICMLYFDFWFQMFNDKKWDSFYSEY----------L 241

  Fly   238 RKNTALV---------LLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGV 292
            .:.|.||         |:..:..|.||.|..||:..|||:|. :..:|||||:.||::.: :|||
Mouse   242 GRPTTLVETMGQAEMWLIRSNWDLEFPHPTLPNVDYVGGLHC-KPAKPLPKDMEEFVQSSGDHGV 305

  Fly   293 IYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGK-PA----NVFISDWFPQDDI 352
            :.||:||.:.:.|  .||..|:....||:.|:|||||:     || ||    |..:..|.||:|:
Mouse   306 VVFSLGSMVSNMT--EEKANAIAWALAQIPQKVLWKFD-----GKTPATLGHNTRVYKWLPQNDL 363

  Fly   353 LAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLA 417
            |.|....||:||||.....|:|||..|.:|||:||:|..|:|.....|..|.::...:|.:.:|.
Mouse   364 LGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLN 428

  Fly   418 AIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLD 482
            |::::|.||...:....:|..:.||...||:|||:|:|.|.|||.||:||....:|.:.|||:||
Mouse   429 ALEEVIENPFYKKNAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLD 493

  Fly   483 AMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            .       |.|:|.|:...|.|..:.|  |||.:...|.:.|.|
Mouse   494 V-------IGFLLSCVATTIVLSVKCL--LFIYRFFVKKENKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/375 (31%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	142/511 (28%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	153/542 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840473
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690