DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	523	Identity:	146/523 - (27%)
Similarity:	252/523 - (48%)	Gaps:	49/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTAGQTGFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKP 67
            |..|.:|.  |||.|.|........||:  ....|.:.....:.:.|.|.||| |::...|:...
Mouse     8 PLRGISGL--LLLLCALPWAEGAKVLVL--PMEGSQWLSMRDVVRELHARGHQ-TVVLASEVTVH 67

  Fly    68 IKN-------------IKDVPAKSILTSMQG--RIANLLQSSKEPIIKQIINFHEMGIEITELLL 117
            ||.             .|:...:.||:.::.  :..:.:::..| ....|.||.::.......||
Mouse    68 IKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFE-TTASIRNFFDLYSNSCIALL 131

  Fly   118 KEPSVIELMKSNQTFDAVISE-VFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYV 181
            ....:|:.:.|: .||.:::: :|...|  ..|::.:.|.:.:....:.....:....|:|.||:
Mouse   132 HNKMLIQQLNSS-FFDVILTDPIFPCGA--VLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYI 193

  Fly   182 PSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLL 246
            |:.|.:.||.|..::||.|..:    |:.|.|       :......|........:::..:||.:
Mouse   194 PNLLTRLSDHMDFLQRVQNMLY----YLVLKY-------ICRLSITPYESLASELLQREVSLVEV 247

  Fly   247 NQHVS---------LSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNL 301
            ..|.|         |.:|||..|||:.:||::...|: ||.::...::..: |||::.||:||.:
Mouse   248 LSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKK-PLSQEFEAYVNASGEHGIVVFSLGSMV 311

  Fly   302 KSKTLPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGG 366
            ..  :|.:|...:.:...::.|.|||::..|.......|..:..|.||:|:|.|....|||||.|
Mouse   312 SE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 374

  Fly   367 LLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQR 431
            .....|.|.:..|.|.:|:||||..|..|.|..|.|||::..|:::..|..|::.:|||....:.
Mouse   375 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 439

  Fly   432 VRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLY 496
            :..:|..::|:...||:.||:|||:|.|||||.:||.|:.||.:.|||:||.:..|...::.|::
Mouse   440 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVF 504

  Fly   497 CIF 499
            .:|
Mouse   505 IVF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	105/359 (29%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	138/501 (28%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	26/136 (19%)
		egt	<261..505	CDD:223071	88/246 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840636
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690