DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and ugt-18

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	137/547 - (25%)
Similarity:	238/547 - (43%)	Gaps:	57/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFEL--KKPI---K 69
            |..:|.|.|:.....|..||.......||.:....::..|..|||.||::.|..|  ||..   |
Worm     3 FALILFFVLIHSTLTYKVLVFNPAYGASHSNFLGKISDILIDAGHNVTMLIPEYLITKKDFVGSK 67

  Fly    70 NIKDVPAKSILTSMQGRIANLLQSS------------KEPIIKQIINF-HEMGIEI---TELLLK 118
            .:|||    :......|...|.:..            .:|.:..::.. ..|.:.|   .|.:.:
Worm    68 KVKDV----VRIGRDERAGKLFEEEGIEHMGRARVWRMDPEMMSLVTIVGSMNLAIGYQCEYIFQ 128

  Fly   119 EPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLV--------GSP 175
            :..:|:.:: |:.||..|:| .|....|...:|       :|....|:..::|.        |.|
Worm   129 QKDIIDRLR-NEHFDLAITE-SLFACPFALFDH-------IGIKNVINAESNLFKDAVKYAHGEP 184

  Fly   176 SPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQE---VLYRKYFPNNKQDFYDM 237
            :..||.|.......|:||.|.||.|...:    :|..|.|..|.|   .:.:.|: |..:.:.|:
Worm   185 AAISYYPGLFSPHDDKMSFVARVKNMITM----LFTKYLYGSRYEKELEMIKPYY-NGTETWEDL 244

  Fly   238 RKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHI--NRKRQPLPKDILEFIEGAEHGVIYFSMGSN 300
            ....|..|:|.:..:.:|.|..|..:.||||.:  |..:..|..:....:...:..|: .|.|||
Worm   245 FTGVAFNLINSNQYIDYPSPALPKTVFVGGMQVNTNEAKTKLSDEWNNILNIRKQNVL-ISFGSN 308

  Fly   301 LKSKTLPLEKRQALIDTFAQLKQ-RVLWKFEDTD--LPGKPANVFISDWFPQDDILAHDNVLAFI 362
            ..|..:|.|.:::.:..|..:.: ..:||:|:.:  |.....||.::.|.||:|:||.|.:..|:
Worm   309 AFSSEMPEEFKKSFLYVFGNMPEITFIWKYEEANATLTSHLPNVKLTTWMPQNDLLADDRLTLFV 373

  Fly   363 THGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEEL-SSAKLLAAIQKIINNP 426
            |||||.||.|..|..||.:.||:..||..|....:::|..:..|...| .|.:||.|.:.::...
Worm   374 THGGLGSTMELAYQGKPALIIPLMADQPRNAHMLKRHGGCLQYHKTMLGDSEQLLKAFKTVLTER 438

  Fly   427 EATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGI 491
            :.::..:.::...|||..:|.:..:...|....|.....|.|..:.||..|:::.|....:....
Worm   439 KYSENAQRLARILRDQPVSPKDLVLKHCEFAVEHGALNSLNSRGRYLNTFQFYSFDIASSIVMLA 503

  Fly   492 IFVLYCIFLLIRLVWRLLQELFIKKDT 518
            :.||..|:..:..:::|:..:|:.:.|
Worm   504 LLVLVFIYFTLLFIFKLVARIFLSQKT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	96/365 (26%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	129/511 (25%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	69/252 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810