DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and ugt-22

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	130/538 - (24%)
Similarity:	243/538 - (45%)	Gaps:	50/538 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GQTGFLALLLFCLLSCVSAYN-YLVVLHTAARSHYHVG--SALAKGLAAAGHQVTIISPF----- 62
            |:..||..||..|.|.|.... |.::::|....|.|:.  .|::..|..|||.:|::.|.
Worm     2 GKNTFLLPLLLLLGSFVGLTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHDLTVLMPVIDFKQ 66

  Fly    63 ELKKPIKNIKDV----PAKSI---LTSMQGRIANL-LQSSKEPIIKQIINFHEMGIEI-----TE 114
            |.|..:|:.|::    |.:.|   :.:|:..:..| ...:..|:   .:.||...:..     ..
Worm    67 ENKTAMKSTKNIIKIQPGQDISKTIETMEKFMTQLWTTDNSNPL---FMVFHAPAMSAIFASQCR 128

  Fly   115 LLLKEPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPL-IGLGTFGAISWNTDLVGSPSPP 178
            .:|::..:||.::: :.||..|:|.| :...:...|..|... :.:.:...:...:..:|.|..|
Worm   129 KVLEDKELIERLRA-ENFDLAITEPF-DTCAYALFEAIKIRAHVAVLSCSRLDHVSKAIGQPIAP 191

  Fly   179 SYVPSALLKFSDRMSLVERVGN-QAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTA 242
            ||||.......:||::.:|..| ..||..:::|   .|:..::....|......:.:.::....:
Worm   192 SYVPGTQSTHGERMTIWQRFMNILHFLMGDFLF---SYIGDEDFKVAKEIIPGVRSWREVLPEAS 253

  Fly   243 LVLLNQHVSLSFPRPYSPNMIEVGGMHI--NRKRQPLPKDILEFIEGAEHGVIYFSMGSNLKSKT 305
            .:..|....:.||.|....:|.:||:.:  .:|...||:...:.: |.....|..|.|||.:|..
Worm   254 FIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNKIL-GLRKKNILVSFGSNARSAD 317

  Fly   306 LPLEKRQALIDTFAQLKQ-RVLWKFE---DTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGG 366
            :|...:|.::.....:.. ..:||:|   || |.....||::.||.||:::|....:..|:||||
Worm   318 MPEHFKQNVLKVAESMPDVTFIWKYENEKDT-LADHLDNVYLGDWLPQNELLGDPRLSLFVTHGG 381

  Fly   367 LLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLA-AIQKIINNPEATQ 430
            |.|.||.....||.|.:|:|.||..|....:::|....:|..:|.:|:.:. .|:|::.|.:...
Worm   382 LASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIRNTIKKVLENEKYRV 446

  Fly   431 RVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQD-----LNFIQYHNLDAMLILYGG 490
            ....:::...:|...|.:..:..||.     .||:.:..|.|     .::|:|:.||.:.|....
Worm   447 NAERLAEMLNNQPTNPKDTLIKHVEF-----AAKFGQLPSMDPYGRHQSYIEYYLLDIISIALVL 506

  Fly   491 IIFVLYCIFLLIRLVWRL 508
            |:...:..|.||:..:|:
Worm   507 ILTTSFISFQLIKCTFRM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	88/357 (25%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	119/504 (24%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	70/265 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14115
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810