DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	154/550 - (28%)
Similarity:	247/550 - (44%)	Gaps:	59/550 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFEL---KKPIKNIK 72
            |..|...||..||||.|.|.:...|.|.....:.:|:.||..||.||:|....|   |..:|..|
Worm     3 LIALFLLLLGAVSAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMIHLSHLPDYKTDVKIPK 67

  Fly    73 DVPAKSILTSMQGRIANLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVI-------------- 123
            ::....:...::|....||:..:...|     |.:.|::....::...|..
Worm    68 NIKVHRVEAYVEGLTKALLEKEQSAFI-----FKDTGLKDMPAMMSMFSRFGKMFQDGCRNIVRN 127

  Fly   124 -ELMK--SNQTFDAVISEVFLNEAHFGFAEHFKAP-LIGLGTFGAISWNTDLVGSPSPPSYVPSA 184
             |.||  .|:.||...|.:: :....|.....|.| .:.|.:...:.:..:.||.|..|||||..
Worm   128 KEFMKWLENEKFDVAYSYIY-SSCPIGLIHAAKIPSWVWLNSGALMDFVAETVGVPIIPSYVPPL 191

  Fly   185 LLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFY-------------D 236
            :::..|.|....|:  ::|:.:..:          .||:|:...|.:...:             |
Worm   192 MMESDDEMGFFFRM--KSFIGHTLM----------TVLHRRMTSNGETQIFRDELNDPNFPHTMD 244

  Fly   237 MRKNTALVLLNQHVSLSFPRPYSPNMIEVGGMHIN-RKRQPLPKDILEFIEGAEHGVIYFSMGSN 300
            :.....||::|.:.....|||....::.:||:.:. ...:||..:..:..|..: |:|.||.||.
Worm   245 LGAKCPLVIVNSNELYDLPRPTLAKVVNIGGLGVGFDSAKPLTGEFKKISETGK-GMIVFSFGSV 308

  Fly   301 LKSKTLPLEKRQALIDTFAQLKQ-RVLWKFEDTDLPGK-PANVFISDWFPQDDILAHDNVLAFIT 363
            ..:..:|||.:.::::.|:.|.. :.|.::...||..: |.||.:..|.||.|:|.|:...||||
Worm   309 AAAHDMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDRLPKNVHLFKWLPQKDLLLHNKTKAFIT 373

  Fly   364 HGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEA 428
            |||..|..|:|....|.|.|.:||||..|...|:::|:.|.:...|:|...::.||.:|:.|...
Worm   374 HGGYNSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISKKTIVKAIMEIVENDSY 438

  Fly   429 TQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIF 493
            .|:|..:|...|.|...|.||.:.|.|.::..|....|..|.|.|||.|||:||.:..|:..|..
Worm   439 KQKVSRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDNLEPAGQKLNFFQYHSLDVITFLFIVIFI 503

  Fly   494 VLYCIFLLIRLVWRLLQELFIKKDTSKPKQ 523
            |.|..:..:|.|.|.   .|.||..:|.|:
Worm   504 VFYIGYRFMRAVIRC---CFCKKCETKTKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	101/382 (26%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	137/504 (27%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	71/220 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2570
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860