DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and UGT3A2

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	XP_011512290.1	Gene:	UGT3A2 / 167127	HGNCID:	27266	Length:	550	Species:	Homo sapiens

Alignment Length:	571	Identity:	160/571 - (28%)
Similarity:	254/571 - (44%)	Gaps:	98/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGQ-----TGFLALLLFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIIS---- 60
            |||     .||  ||...|||..:.   ::.:.|...|||.:...:::.|...||.||:::
Human     2 AGQRVLLLVGF--LLPGVLLSEAAK---ILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRG 61

  Fly    61 PFELKKPIKNIKDVPAKSILTSMQGRIA--------NLLQSSKEPIIKQIINF-----HE----- 107
            ||     :..:.|.||.:   |...||.        .|....||....|:|::     |:
Human    62 PF-----MPGLSDSPASA---SRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKK 118

  Fly   108 ---------MG--------IEITELL-------LKEPSVIELMKSNQTFDAVISEVFLNEAHFGF 148
                     :|        :.:.|.|       |....:::.:| |:.||.||.|.| :...|..
Human   119 SFDFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLK-NENFDMVIVETF-DYCPFLI 181

  Fly   149 AEHFKAPLIGL--GTFGAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTYEYIFL 211
            ||....|.:.:  .:||::.:     |.|.|.||||......:|.|....||.|         ||
Human   182 AEKLGKPFVAILSTSFGSLEF-----GLPIPLSYVPVFRSLLTDHMDFWGRVKN---------FL 232

  Fly   212 NYFYLPRQEVLYRKYFPNN-KQDFYD--------MRKNTALVLLNQHVSLSFPRPYSPNMIEVGG 267
            .:|...|::...:..|.|. |:.|.:        :.....|..:|...:..|.||..||.:.|||
Human   233 MFFSFCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGG 297

  Fly   268 MHINRKRQPLPKDILEFI-EGAEHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFED 331
            : :.:..:|:|:|:..|| :..:.|.:..::||.:.:...| |..:.:.:.||.|.|.|:||.:.
Human   298 L-MEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNP-EIFKEMNNAFAHLPQGVIWKCQC 360

  Fly   332 TDLPGK---PANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNM 393
            :..|..   .|||.|.||.||.|:|||.::..|:||||..|..|:|.|..|.||||:||||..||
Human   361 SHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENM 425

  Fly   394 ARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVS 458
            .|.|...:||::..::|.:..|...:::|:.:..........|...|....:|.:|.|.|::||.
Human   426 VRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVL 490

  Fly   459 RHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLY-CIFLLIRLVWRL 508
            :..||.:|:.......:.:.:.||..:.|.|..:..|: |..||...||.|
Human   491 QTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAVWWL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	112/363 (31%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	141/523 (27%)
UGT3A2	XP_011512290.1	egt	<162..517	CDD:223071	114/372 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740