DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	156/519 - (30%)
Similarity:	252/519 - (48%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYHVGSALAKGLAAAGHQVTIISP---FELKKPI-----------------KNIKDVPAKSILT 81
            ||:.....:.:.|...||:|.::.|   ::|.||:                 :..|........|
  Rat    36 SHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYSVSHTQEDLNREFKFFIDSQWKT 100

  Fly    82 SMQGRIANLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVIELMKSNQTFDAVISEVFLNEAHF 146
            ..:|.:..||.|..:       .|.|:.......|.|:..::|.:|.: :||||..:.| :....
  Rat   101 QQEGGVLPLLTSPAQ-------GFFELLFSHCRSLFKDKKLVEYLKQS-SFDAVFLDPF-DVCGL 156

  Fly   147 GFAEHFKAP--LIGLGTFGAISWNTDLVGSPSPPSYVPSALLKFSDRMSLVERVGNQAFLTY--E 207
            ..|::|..|  :...|.|  ..:..:....||||||||..:||.:|.|:..|||.|  .|:|  |
  Rat   157 TVAKYFSLPSVVFSRGIF--CHYLEEGSQCPSPPSYVPRGILKLTDTMTFKERVWN--LLSYMGE 217

  Fly   208 YIFLNYFYLP----RQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEVGGM 268
            :.|...|:..    ..|||..   |....|.:   ...::.||....:|..|||..||:|.:||:
  Rat   218 HAFCPSFFKTATDIASEVLQT---PVTMTDLF---SPVSVWLLRTDFTLELPRPVMPNVIHIGGI 276

  Fly   269 HINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKFEDT 332
            :.: :|:||.|:...::..: |||::.||:||.:..  :|.:|...:.:...::.|.|||::..|
  Rat   277 NCH-QRKPLSKEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGT 338

  Fly   333 DLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMARAE 397
            .......|..:..|.||:|:|.|....|||||.|.....|.|.:..|.|.:|:||||..|..|.|
  Rat   339 RPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRME 403

  Fly   398 QNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSRHKG 462
            ..|.|||::..|:::..|..|::.:|||....:.:..:|..::|:...||:.||:|||:|.||||
  Rat   404 TRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKG 468

  Fly   463 AKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIKKDTSKPKQKAK 526
            |.:||.|:.||.:.|||:||.:..|   :..||..:|::.:......::.|..|...|...|:|
  Rat   469 APHLRPAAHDLTWYQYHSLDVIGFL---LAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/357 (33%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	153/510 (30%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	89/246 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136043
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860