DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302C1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	553	Identity:	164/553 - (29%)
Similarity:	274/553 - (49%)	Gaps:	67/553 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLLSC--VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTII----SP---------FE 63
            ||.|||.|  ...::..|::.....||:|...|:.:.|....|.||::    ||         |:
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYSHWHNMRAIIEALVDRNHSVTVLVGSSSPTVPHTQKARFD 70

  Fly    64 LKKPIKNIKDVPAKSILTSMQGRIANLLQSSKEPI--IKQIIN-FHEMGIEITELLLKEPSVIEL 125
            ......||:...|.::.:.......|...:..|.:  |.|::: |..:..|:.:.:.|| .::::
Zfish    71 YHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVMSRFMTLTDEVCKGMFKE-DLLQM 134

  Fly   126 MKSNQTFDAVISEVFLNEAHFGFAEHFKAPLI-GLGTFGAISWNTDLVGSPSPPSYVPSALLK-- 187
            ::.:. :|.:.|:..:..:.. .|:....||: .|....|.|:.......|:||||||:|.|:
Zfish   135 LRESH-YDVLFSDPMMPCSDL-MAQTLNIPLVLSLRATFAYSFERMCGQMPAPPSYVPAASLRDH 197

  Fly   188 FSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFY-DMR-KNTALV------ 244
            .:||||.:|||.|         .|.||   ..:|.::.|........| ::| |.|.:.
Zfish   198 LTDRMSFMERVEN---------MLLYF---SHDVFFKLYMMFTFDRIYTEIRGKPTTMCETMGKA 250

  Fly   245 ---LLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKT 305
               |:..:....:|||:.||...|||:|. :..:||.|::.||::.: :|||:.||:||.:|:
Zfish   251 DIWLIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEMEEFVQSSGDHGVVVFSLGSMIKN-- 312

  Fly   306 LPLEKRQALIDTFAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLST 370
            |..|:...:.....|:.|:|:|::..........|..|.||.||:|:|.|....|||||||....
Zfish   313 LTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGL 377

  Fly   371 TESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDM 435
            .|:|||..|.||:|:|.||..|:...:..|..|.:....|.|..|:.|::.::|||...:.:..:
Zfish   378 YEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRL 442

  Fly   436 SDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLD--AMLILYGGIIFVLY-- 496
            |..:.||...||::||||:|.|.|:||||:||..:.:|::.|||.||  |.|:....:|..|:
Zfish   443 SRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWVK 507

  Fly   497 -CIFLLIRLVWRLLQELFIKKDTSKPKQKAKRN 528
             |.||..|.|.:           ::|::|.:::
Zfish   508 ACCFLFRRCVRK-----------TRPERKTQKS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	118/363 (33%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	156/515 (30%)
		REC	<129..>178	CDD:302758	9/51 (18%)
		egt	<254..485	CDD:223071	85/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930