DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302C1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	550	Identity:	164/550 - (29%)
Similarity:	268/550 - (48%)	Gaps:	62/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFCLLSCVSAYN-----YLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISP-----FELKKPI 68
            |:.|.||.::.::     .::|.||.. ||:.....:...|...||.||::.|     .:.|:..
Zfish     3 LVVCFLSLLTVFSAGQCGNILVWHTEG-SHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKESD 66

  Fly    69 K-NIKDVPAKSILTSMQGRIANLLQSS----KEPIIKQI-INF-------HEMGIEITELLLKEP 120
            : :.::....:....||..:..||..|    ::..:.|| :.|       .:||:...:.:||.|
Zfish    67 RFSYQNFSVSTSAQDMQDFLDELLHFSVFEMEQLNLLQIQMKFFDLGSRHQDMGLSYCDGILKSP 131

  Fly   121 SVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGS-PSPPSYVPSA 184
            .:::.:|:.: ||.::|:.....:.. .||....||:....|........:.|. |:||||||.|
Zfish   132 ELMDKLKTGK-FDVLLSDPMYPCSDI-VAEVLNVPLVFTLRFSIAHTMERICGQIPAPPSYVPGA 194

  Fly   185 LLKFSDRMSLVERVGNQAFL----TYEYI----FLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNT 241
            :.|.:|:||..||:.|..|.    |:..|    |.||         |.:|| .....:.:|....
Zfish   195 MSKLTDKMSFTERIFNTLFYLSMDTFSIIAWKKFDNY---------YTEYF-GRPTSYCEMMGRA 249

  Fly   242 ALVLLNQHVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKT 305
            .:.|:..:....||||:.||...:||:|.. ..:|||||:.||::.: :.|::.|::||.:..
Zfish   250 DIWLIRTYWDFEFPRPFVPNFKYIGGLHCT-PAKPLPKDMEEFVQSSGDDGIVVFTLGSMIDK-- 311

  Fly   306 LPLEKRQALIDTFAQLKQRVLWKF--EDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLL 368
            :|.|....:....||:.|:|||::  |..|..|:  |..|..|.||:|:|.|....|||||||..
Zfish   312 VPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGE--NTRIYKWMPQNDLLGHPKTRAFITHGGTN 374

  Fly   369 STTESIYHRKPFVGIPIFGDQFLNMARAEQNGYGVTV-HYEELSSAKLLAAIQKIINNPEATQRV 432
            ...|:|||..|.||||:||||..||......|..|.| ..:.:...:|:..:..:||:|...:..
Zfish   375 GIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLNTVINDPSYKENA 439

  Fly   433 RDMSDRYRDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYC 497
            ..:|..:.|:...||:.:|:|:|.|.|:||||:||..:.:|.:.|||.||....|...:..|||.
Zfish   440 MRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTVLTLVLYI 504

  Fly   498 IFLLIRLVWRLLQELFIKKDTSKPKQKAKR 527
            .|.:.:        .||.:...:.|:|:|:
Zfish   505 CFKMAK--------FFIMRCCFRSKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	120/361 (33%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	158/528 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584923
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690