DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	540	Identity:	163/540 - (30%)
Similarity:	249/540 - (46%)	Gaps:	106/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVETPN 75
            |.|.|:....|...|::....  ||:.....:.:.|:..||::.::                .|.
Mouse    16 LFLVLWASVLGDKLLVVPQDG--SHWLSMKEIVEHLSERGHDIMVL----------------VPE 62

  Fly    76 IITVMG---VYKARI--LENAKKPVLLRY---------PRISLMG-----------LDI----TE 111
            :..::|   .|:.:|  :..:.:.:..|:         |..||||           :|:    .:
Mouse    63 VNLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQ 127

  Fly   112 SLLKEPKVQELLKQNRTFD----------GVICETFMN-DAHYGFAEHFGAPLITLSSLGATGWT 165
            ||||:......|::|: ||          |||...::| .:.|.|.   |.|......||.
Mouse   128 SLLKDSATLSFLRENK-FDALFTDPAMPCGVILAEYLNLPSVYLFR---GFPCSLEHMLGQ---- 184

  Fly   166 SDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKY------- 223
                 :|||.||||....:|.|.|.|.:|..|....|    .||.:    :..||.||
Mouse   185 -----SPSPVSYVPRFYTKFSDHMTFPQRLANFIVNI----LENYL----YYCLYSKYEIIASDL 236

  Fly   224 ------FPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKF 282
                  .|:..|:        ||.||........|||..||||.:||::..:|.  .|.|....:
Mouse   237 LKRDVSLPSLHQN--------SLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKG--KLTQEFEAY 291

  Fly   283 IE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLP 346
            :. ..|||::.|||||.::  ::||.|...|.|.|..:...|:|:|......:...|.::..|||
Mouse   292 VNASGEHGIVVFSLGSMVS--EIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLP 354

  Fly   347 QDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTAS 411
            |:|:|.|.|..|||||.|.....|.|.:|.|:|.:|.||||..|..|.|..|.|:|:...::||.
Mouse   355 QNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTAD 419

  Fly   412 LFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQY 476
            ...:|::.:.::.|:.|.:..:||.::|:...||:.||:|||:|.|||||.:||.|..||.:.||
Mouse   420 DLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQY 484

  Fly   477 HNLDVLATFFSVIGLTVIFV 496
            |:|||:. |...|.|||:|:
Mouse   485 HSLDVIG-FLLAIVLTVVFI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	123/374 (33%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	162/538 (30%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	159/529 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840698
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.640