DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	157/552 - (28%)
Similarity:	262/552 - (47%)	Gaps:	83/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP----FPQR 62
            :|:  |.|||:...|....|....::......||:.....:.:.|...|||||::.|    |...
  Rat     4 KWI--SALLLLQISFCFKSGNCGKVLVWPMEYSHWMNIKIILEELVQKGHEVTVLRPSASVFLDP 66

  Fly    63 KPIKNIIDVETPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNR 127
            |...::      ..:|....:.:..|||    ...|:..:....|.....|.....:|:.:.:..
  Rat    67 KETSDL------KFVTFPTSFSSHDLEN----FFTRFVNVWTYELPRDTCLSYFLYLQDTIDEYS 121

  Fly   128 TFDGVICETFMNDAHY-----------GFAEHFG------APLITLSSL----GATGWTSD--LV 169
            .:...:|:..:::..:           .|::..|      |.|:.:..|    .:.|:|.:  :.
  Rat   122 DYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAIGPCGELIAELLQIPFLYSLRFSPGYTIEKYIG 186

  Fly   170 GTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIY-EFAYENLINLPRHEALYRKYFPNNKQD-FY 232
            |...||||||........:|.|.||..|:...:| :|.::.              |...|.| ||
  Rat   187 GVLFPPSYVPMIFSGLAGQMTFIERVHNMICMLYFDFWFQT--------------FREKKWDPFY 237

  Fly   233 --RMRKDTSLV---------LLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA 286
              .:.:.|:|.         |:.::..:..|.|.|||:..:||:|.  |..||||::|..|::.:
  Rat   238 SKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHC--KPAKPLPKDIEDFVQSS 300

  Fly   287 -EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKP----DNVLISNWLP 346
             ||||:.|||||.:  :::.|.|...|...|..:..:|:|:::.:    ||    .|..:..|||
  Rat   301 GEHGVVVFSLGSMV--RNMTEEKANIIAWALAQIPQKVLWRFDGK----KPPTLGPNTRLYKWLP 359

  Fly   347 QDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTAS 411
            |:|:|.|.|..||:||||.....|:|:||.|::|||.||:|..|:|.....|..:.|.:..::.|
  Rat   360 QNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKS 424

  Fly   412 LFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQY 476
            ...:|:|.:.::|.:.:....:|:.:.||...||:|||:|:|.|.||||||:|||...:|.:.||
  Rat   425 DMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQY 489

  Fly   477 HNLDVLATFFSVIGLTVIFV---FLLV-RFLV 504
            |:|||:....:.:.:||:..   ||.| ||.|
  Rat   490 HSLDVIGFLLTCVAVTVVLALKCFLFVYRFFV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	114/390 (29%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	150/530 (28%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	86/226 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344106
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690