DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	550	Identity:	159/550 - (28%)
Similarity:	257/550 - (46%)	Gaps:	91/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI 65
            ||...::.:.|:|.||....|:...::......||:.....:.:.|...|||||:::   ..||
Human     1 MRSDKSALVFLLLQLFCVGCGFCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLT---HSKP- 61

  Fly    66 KNIIDVETPNII--TVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNRT 128
             ::||...|:.:  .|:.:.:.|..||   .:.:......|.||...:|::   |:.:...:.|.
Human    62 -SLIDYRKPSALKFEVVHMPQDRTEEN---EIFVDLALNVLPGLSTWQSVI---KLNDFFVEIRG 119

  Fly   129 FDGVICETF---------MNDAHYG-------------FAEHFGAPLITLSSLGATGWTSDLVG- 170
            ...::||:|         :.:.:|.             .||....|.:....:...|......|
Human   120 TLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVGGNMERSCGK 184

  Fly   171 TPSPPSYVPHSLLRFGDRMNFWERAQN------LGFQIYEFAYENLINLPRH--EALYRKYFPNN 227
            .|:|.||||..:....|||.|.||.:|      ..|.|.::.|        |  |..|.|
Human   185 LPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDY--------HFWEEFYSK----- 236

  Fly   228 KQDFYRMRKDTSLV---------LLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLP------Q 277
                 .:.:.|:|.         |:..:.....|:||.||...|||:|.  |..|.||      |
Human   237 -----ALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHC--KPAKALPKINFYLQ 294

  Fly   278 NIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPD---- 337
            .:..|::.: |.|::.|||||..  :::.|.|...|...|..:..:|:|:|:.:    ||.
Human   295 EMENFVQSSGEDGIVVFSLGSLF--QNVTEEKANIIASALAQIPQKVLWRYKGK----KPSTLGA 353

  Fly   338 NVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGIT 402
            |..:.:|:||:|:|.|.|..|||||||:....|:||||.|:||:|.||||..|:|..:..|..:.
Human   354 NTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVE 418

  Fly   403 VKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSA 467
            :.:..:|:.....|:..:.:|.|:.|....:|..:.||...||:|||:|:|.|.||||||:||||
Human   419 INFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSA 483

  Fly   468 CQDLNFIQYHNLDVLATFFSVIGLTVIFVF 497
            ..||.:.|::::||:....:.:. |.||:|
Human   484 AHDLTWFQHYSIDVIGFLLACVA-TAIFLF 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	118/400 (30%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	151/526 (29%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	91/238 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150237
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690