DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	529	Identity:	153/529 - (28%)
Similarity:	242/529 - (45%)	Gaps:	63/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVET 73
            ||:.|.|.|...|:|..::......||:.....:.:.|....|.||:            ::...:
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYSHWHNMRPVIEALVDKNHSVTV------------LVGSSS 58

  Fly    74 PNIITVMGVYKAR-----ILENAKKPVLLRYPRISLMGLDITESLLKEPKV-------------- 119
            |   ||....|.|     ...|.:|.| :.|..|....|.:.|::....|.
Zfish    59 P---TVPHTQKERFEYHVFKVNMEKEV-VDYLWIHFHELWMNETISTYEKTLEVWQLMSLFRAHS 119

  Fly   120 QELLKQNRTFDGVICETFMNDAHYG-------------FAEHFGAPLITLSSLGATGWTSDLVG- 170
            :||:|  ..||..:.:| :.|::|.             .|:....|.:....:........|.|
Zfish   120 EELVK--GLFDVGLLKT-LRDSNYDVLFSDLTMPFSDLMAQKLNIPHVLSMRISFASALERLCGQ 181

  Fly   171 TPSPPSYVPHSLLR--FGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYR 233
            .|.|.||||.::.:  ..|||:|.||.:|:...|...|...|......:.:|.: ..........
Zfish   182 MPVPQSYVPAAVAQGHLTDRMSFTERVENMLLYITHTAMFQLTTKFTFDHIYAE-ISGEPTTMCE 245

  Fly   234 MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGS 297
            ....|.:.|:..:.....|||:.||...|||:..  |..|||.:.:.:|::.: :||::.|||||
Zfish   246 TIGKTDIWLIRTYWDFEYPRPFPPNFKFVGGLQC--KPAKPLAKELEEFVQSSGDHGIVVFSLGS 308

  Fly   298 NLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITH 362
            .:  |:|...|...|...|..:..:|:|:|..:|......|..|.:|:||:|:|.|.|..|||||
Zfish   309 MI--KNLTVQKANTIAAALGQISQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITH 371

  Fly   363 GGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFT 427
            ||.....|:||||.|:||:|.||||..|:...:..|..:.:.:..|.:.....|::.:.::||:.
Zfish   372 GGTNGLYEAIYHGVPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLNNPSYK 436

  Fly   428 ERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLT 492
            |.:..:|..:.||...||::||||:|.|.|:||||:||....:|::.|||.|||.|...|:   |
Zfish   437 ESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSI---T 498

  Fly   493 VIFVFLLVR 501
            .:..||.|:
Zfish   499 ALITFLWVK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/380 (30%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	146/514 (28%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	85/234 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830