DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	550	Identity:	159/550 - (28%)
Similarity:	246/550 - (44%)	Gaps:	104/550 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVT-LVS------PFPQR---- 62
            ||:.|.|.|...|:|..::......||:....|:.:.|....|.|| |||      |..|:
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYSHWHNMRAIIEALVDRNHSVTVLVSSSSPTVPHTQKARFD 70

  Fly    63 -KPIKNIIDVETPNII---------------TVMGVYKARILENAKKPVLLRYPRISLMGLDITE 111
             ...|..:|.|...:|               ...|....|::.|.::           :..|:..
Zfish    71 YHVFKVNMDKEEAKVIWSDFTHLWMKETDSKLERGFLIWRVMSNFRR-----------LAADVCR 124

  Fly   112 SLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGAT-------------- 162
            |||:...:.::|               .::||...  |..|::..|.|.|.
Zfish   125 SLLQNDDLLQML---------------GESHYDVL--FSDPMMPCSDLMAQTLNIPQVISLRLTF 172

  Fly   163 GWTSD-LVG-TPSPPSYVPHSLL--RFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKY 223
            .:|.: :.| .|:||||||...|  ...|||:|.||.:|:   :..|.:..:..|.....:.|.|
Zfish   173 AYTFERMCGQMPAPPSYVPAVALTDHLTDRMSFMERVENM---LLYFIHTTVFRLNTMLTVDRLY 234

  Fly   224 F-----PN------NKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQ 277
            .     |.      .|.|.:         |:..:.....|||:.||...|||:|.  |..|||.:
Zfish   235 TEIRGKPTTMCETMGKADIW---------LIRTYWDFEYPRPFPPNFKFVGGLHC--KPAKPLSK 288

  Fly   278 NIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLI 341
            .:.:|::.: :|||:.|||||.:  |:|...:...|...|..:..:|:|:|..:|......|..|
Zfish   289 EMEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKI 351

  Fly   342 SNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYA 406
            .:|:||:|:|.|.|..|||||||.....|:||||.|:||:|.|.||..|:...:..|..:.:...
Zfish   352 YDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDIN 416

  Fly   407 QLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDL 471
            .|.:.....|::.:.::||:.|.:..:|..:.||...||::||||:|.|.|:||||:||....:|
Zfish   417 TLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHEL 481

  Fly   472 NFIQYHNLDVLATFFSVIGLTVIFVFLLVR 501
            ::.|||.|||.|...|:..|   ..||.|:
Zfish   482 SWYQYHCLDVAAFLLSIAAL---ITFLWVK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	115/379 (30%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	152/534 (28%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	85/234 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860