DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	530	Identity:	154/530 - (29%)
Similarity:	247/530 - (46%)	Gaps:	65/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVET 73
            ||:.|.|.|...|:|..::......||:.....:.:.|....|.||:            ::...:
Zfish     6 LLVCLLLCGVDVGWSGRVLVMPGEYSHWHNMRPVIEALVDKNHSVTV------------LVGSSS 58

  Fly    74 PNIITVMGVYKARI--------LENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQ----- 125
            |   ||....|.|.        :|..:....:| ..|.|...|.......|..:.:::.:
Zfish    59 P---TVPHTQKERFEYHVFKVNMEKEEADAAMR-DMIHLFTNDTAAKYEGEFVMWKVMSKFVEFG 119

  Fly   126 ----NRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGAT--------------GWTSD-LVG- 170
                ...||..:.:| :.|::|...  |..|::..|.|.|.              .:.:: |.|
Zfish   120 DVYFRGLFDVGLLKT-LRDSNYDVL--FSDPMMPFSDLMAQKLNIPQVISMRATFAYAAERLCGQ 181

  Fly   171 TPSPPSYVPHSLL--RFGDRMNFWERAQN-LGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFY 232
            .|:||||||...|  ...|||:|.||.:| |.:.::..|:. |:.....:..|.:..........
Zfish   182 MPAPPSYVPAVALTDHLTDRMSFMERVENMLLYIVHSIAFP-LVATFTFDGYYSEILGKPTTMCE 245

  Fly   233 RMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLG 296
            .|.| ..:.|:..:.....|||:.||...|||:|.  |..|||.:.:.:|::.: :|||:.||||
Zfish   246 TMGK-VDICLIRTYWDFEYPRPFPPNFKFVGGLHC--KPAKPLSKELEEFVQSSGDHGVVVFSLG 307

  Fly   297 SNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFIT 361
            |.:  |:|...:...|...|..:..:|:|:|..:|......|..|.:|:||:|:|.|.|..||||
Zfish   308 SMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFIT 370

  Fly   362 HGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSF 426
            |||.....|:||||.|:||:|.||||..|:...:..|..:.:....:.:.....|::.:.::||:
Zfish   371 HGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSY 435

  Fly   427 TERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGL 491
            .|.:..:|..:.||...||::||||:|.|.|:||||:||....:|::.|||.|||.|...|:
Zfish   436 KESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSI--- 497

  Fly   492 TVIFVFLLVR 501
            |.:..||.|:
Zfish   498 TALITFLWVK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	116/378 (31%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	147/515 (29%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	86/240 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585037
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690