Protein Alignment Ugt302E1 and UGT8

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 156/548 - (28%)
• Similarity: 262/548 - (47%)
• Gaps: 85/548 - (15%)

  Fly     8 WLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVE 72
            :.:|:.:..|.:.....:::.....:||..:...||..|...||.
Human     7 YFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHH-------------------- 51

  Fly    73 TPNIITVMGVYKARILENAKKPVLLRYP----------------------RISLMGL-DITESLL 114
                 ||..:.:.|.:..:....|.|||                      |::.:.| ||.:...
Human    52 -----TVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYT 111

  Fly   115 K--------EPKVQELLKQNRTFDGVICETFMNDAHYGF--AEHFGAPLITLSSLGATG-WTSDL 168
            |        ...:|.|.|:.  ||.::.:.  ||. .||  |...|......|    || |....
Human   112 KNCDLMVGNHALIQGLKKEK--FDLLLVDP--NDM-CGFVIAHLLGVKYAVFS----TGLWYPAE 167

  Fly   169 VGTPSPPSYVP--HSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDF 231
            ||.|:|.:|||  :|||.  ||||..:|.:|.|..:......:.:.||::|.:.:||....::..
Human   168 VGAPAPLAYVPEFNSLLT--DRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSM 230

  Fly   232 YRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSL 295
            |.:...:||.:|...|::..|||..||::.|||  :..|...|||:::::::..| |||.:..|.
Human   231 YDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGG--ILTKPASPLPEDLQRWVNGANEHGFVLVSF 293

  Fly   296 GSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFI 360
            |:.:  |.|.|:....:...|..|..:|||::......:..:|..:..||||:|:|.|.|:.||:
Human   294 GAGV--KYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFL 356

  Fly   361 THGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPS 425
            :||||.|..|:||||.||||||.|||.:..|.|.:..|.||.:::..:|......|:.::.::||
Human   357 SHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPS 421

  Fly   426 FTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIG 490
            :.:|.:.:|..::||...|:.|.:||::::.||.||.:||:|...::|.||..||:  .|..::|
Human   422 YRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDI--AFVLLLG 484

  Fly   491 LTVIFVFLLVRFLVTIVNGFLYKPSSKL 518
            ..:::      ||::.|..|:|:....|
Human   485 AALLY------FLLSWVTKFIYRKIKSL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	113/328 (34%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	153/528 (29%)