Protein Alignment Ugt302E1 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 157/546 - (28%)
• Similarity: 258/546 - (47%)
• Gaps: 90/546 - (16%)

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI 65
            ::| ::.:||:.|:.:..|.....:::..| ..||:.....:.:.|...||||.:::.
Human     3 LKW-MSVFLLMQLSCYFSSGSCGKVLVWPT-EYSHWINMKTILEELVQRGHEVIVLTS------- 58

  Fly    66 KNIIDVETPNIITVMGVYKARILENAKKPVLLR---YPRISLMGLDITESLLKE----------- 116
                              .|.||.||.|...::   || .||...|:.:..:|.
Human    59 ------------------SASILVNASKSSAIKLEVYP-TSLTKNDLEDFFMKMFDRWTYSISKN 104

  Fly   117 ------PKVQELLKQNRTFDGVICE----------------------TFMNDAHYGFAEHFGAPL 153
                  .::|||..:...::..:||                      ..:|......||....|.
Human   105 TFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPF 169

  Fly   154 ITLSSLGATGWTSDLVGTP--SPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRH 216
            : .|...:.|:|.:..|..  .||||||..:....|:|.|.||.:|:.:.:|...:....:|.:.
Human   170 L-YSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKW 233

  Fly   217 EALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRK 281
            :..|.:........|..|.| ..:.|:..:.....|||:.||:..|||:|.  |..||||:.:.:
Human   234 DQFYSEVLGRPTTLFETMGK-AEMWLIRTYWDFEFPRPFLPNVDFVGGLHC--KPAKPLPKEMEE 295

  Fly   282 FIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISN-- 343
            |::.: |:|::.|||||.::  ::.|.....|...|..:..:|:|:::     .|..|.|.||
Human   296 FVQSSGENGIVVFSLGSMIS--NMSEESANMIASALAQIPQKVLWRFD-----GKKPNTLGSNTR 353

  Fly   344 ---WLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKY 405
               ||||:|:|.|.|..|||||||.....|:||||.|:||||.|.||..|:|..:..|..::|..
Human   354 LYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDI 418

  Fly   406 AQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQD 470
            ..:::....:|::.:.:||.:.|.:..:|..:.||...||:|||:|:|.|.||||||:||.|..:
Human   419 RTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHN 483

  Fly   471 LNFIQYHNLDVLATFFSVIGLTVIFV 496
            |.:||||:|||:|...:.:. |:||:
Human   484 LTWIQYHSLDVIAFLLACVA-TMIFM 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	119/333 (36%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	152/524 (29%)