Protein Alignment Ugt302E1 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 158/528 - (29%)
• Similarity: 268/528 - (50%)
• Gaps: 56/528 - (10%)

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP------- 58
            ::|   :.:|||...|..|.|....::...|..|.:.....:.|.|...|||||:::.
Human     3 LKW---TTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFD 64

  Fly    59 -----------FPQRKPIKNIIDVETPNIITVMGVYKARILENAKKPVLLRYPR-------ISLM 105
                       :|     .::...|..|||  |.:.| |:.|..|....|.:.:       |:.:
Human    65 PNDSSTLKLEVYP-----TSLTKTEFENII--MQLVK-RLSEIQKDTFWLPFSQEQEILWAINDI 121

  Fly   106 GLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSD--L 168
            ..:..:.::...|:.:.|:::| ||.|..:.::..... .||.|..|.:...|. :.|::.:  .
Human   122 IRNFCKDVVSNKKLMKKLQESR-FDIVFADAYLPCGEL-LAELFNIPFVYSHSF-SPGYSFERHS 183

  Fly   169 VGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYR 233
            .|...||||||..:.:..|:|.|.||.:|:.:.:|...:..:.|:.:.:..|.:...........
Human   184 GGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSET 248

  Fly   234 MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGS 297
            ||| ..:.|:.|..:...|.|:.||:..|||:|.  |..||||:.:.:|::.: |:||:.|||||
Human   249 MRK-ADIWLMRNSWNFKFPHPFLPNVDFVGGLHC--KPAKPLPKEMEEFVQSSGENGVVVFSLGS 310

  Fly   298 NLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPD----NVLISNWLPQDDILAHEKVIA 358
            .::  ::.|.:...|...|..:..:|:|:::.    :|||    |..:..|:||:|:|.|.|..|
Human   311 MVS--NMTEERANVIATALAKIPQKVLWRFDG----NKPDALGLNTRLYKWIPQNDLLGHPKTRA 369

  Fly   359 FITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSD 423
            ||||||.....|:||||.|:||||.|.||..|:|..:..|..:.|.:..::::...:|::.:.:|
Human   370 FITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVIND 434

  Fly   424 PSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSV 488
            ||:.|.:..:|....||...||:|||:|:|.|.||||||:||.|..:|.:.|||:|||:....:.
Human   435 PSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLAC 499

  Fly   489 IGLTVIFV 496
            :. ||:|:
Human   500 VA-TVLFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	117/356 (33%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	151/505 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150508
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640